NP_694768.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,246 Da
NCBI Official Full Name
kelch-like protein 12
NCBI Official Synonym Full Names
kelch-like 12
NCBI Official Synonym Symbols
NCBI Protein Information
kelch-like protein 12; kelch-like protein C3IP1; CUL3-interacting protein 1
UniProt Protein Name
Kelch-like protein 12
UniProt Synonym Protein Names
CUL3-interacting protein 1
UniProt Synonym Gene Names
UniProt Entry Name
KLH12_MOUSE
UniProt Comments for KLHL12
KLHL12: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4, KLHL12 and SEC31A. Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Cellular Component: Golgi membrane; cytoplasmic vesicle; ER to Golgi transport vesicle
Biological Process: protein monoubiquitination; vesicle-mediated transport; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Wnt receptor signaling pathway; transport
Research Articles on KLHL12
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Products associated with KLHL12 elisa kit
Pathways associated with KLHL12 elisa kit
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