NP_666105.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
78,971 Da
NCBI Official Full Name
lethal(3)malignant brain tumor-like protein 2 isoform 2
NCBI Official Synonym Full Names
l(3)mbt-like 2 (Drosophila)
NCBI Protein Information
lethal(3)malignant brain tumor-like protein 2; lethal(3)malignant brain tumor-like protein 2; l(3)mbt-like protein 2
UniProt Protein Name
Lethal(3)malignant brain tumor-like protein 2
UniProt Synonym Gene Names
UniProt Entry Name
LMBL2_MOUSE
UniProt Comments for L3MBTL2
L3MBTL2: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Histone-binding
Cellular Component: nucleus
Molecular Function: zinc ion binding; histone binding; metal ion binding; methylated histone residue binding
Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification
Research Articles on L3MBTL2
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Organs/Tissues associated with L3MBTL2 elisa kit
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