NP_034325.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
99,666 Da
NCBI Official Full Name
leucine-rich repeat-containing G-protein coupled receptor 5
NCBI Official Synonym Full Names
leucine rich repeat containing G protein coupled receptor 5
NCBI Official Synonym Symbols
NCBI Protein Information
leucine-rich repeat-containing G-protein coupled receptor 5; follicle expressed hormone; G protein-coupled receptor 49; G-protein coupled receptor 49; orphan G-protein coupled receptor FEX
UniProt Protein Name
Leucine-rich repeat-containing G-protein coupled receptor 5
UniProt Synonym Protein Names
G-protein coupled receptor 49; Orphan G-protein coupled receptor FEX
UniProt Synonym Gene Names
UniProt Entry Name
LGR5_MOUSE
NCBI Summary for LGR5
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
UniProt Comments for LGR5
LGR5: a leucine-rich repeat-containing G-protein-coupled receptor. Receptor for R-spondins, potent stimulators of adult stem cell proliferation. A marker of cycling, long-lived and multipotent adult stem cell populations. Target gene of Wnt signaling. A Wnt receptor component that enhances Wnt signaling by soluble R-spondin proteins. Intestinal Lgr5+ stem cells give rise throughout life to proliferation of cells in crypts, which migrate along the crypt-villus axis, differentiating into five main cell types. Wnt signaling plays a crucial role in the proliferation and differentiation of these crypt epithelial cells. Two isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Cellular Component: Golgi apparatus; membrane; integral to plasma membrane; integral to membrane; plasma membrane; trans-Golgi network membrane
Molecular Function: G-protein coupled receptor activity; signal transducer activity; transmembrane receptor activity; protein-hormone receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; hair follicle development; oocyte differentiation; signal transduction; inner ear development
Research Articles on LGR5
Precautions
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Diseases associated with LGR5 elisa kit
Organs/Tissues associated with LGR5 elisa kit
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