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LRRK2 elisa kit :: Mouse leucine-rich repeat kinase 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS916685
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

leucine-rich repeat kinase 2 (LRRK2), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Leucine-rich repeat serine/threonine-protein kinase 2, LRRK2 ELISA Kit

 Product Synonym Names    Mouse Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) ELISA kit; AURA17; DARDARIN; PARK8; RIPK7; ROCO2; augmented in rheumatoid arthritis 17; leucine-rich repeat kinase 2
 Product Gene Name   

LRRK2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS916685 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for Q5S006
 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of mouse LRRK2. No significant cross-reactivity or interference between mouse LRRK2 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, cell lysates
 Assay Type    Quantitative Sandwich
 Detection Range    34.37 pg/ml -2200 pg/ml
 Sensitivity    Typically less than 8.59 pg/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LRRK2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LRRK2 purchase    MBS916685 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the leucine-rich repeat kinase 2 (LRRK2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 34.37 pg/ml -2200 pg/ml in biological research samples containing LRRK2, with an estimated sensitivity of Typically less than 8.59 pg/ml. The ELISA analytical biochemical technique of the MBS916685 kit is based on LRRK2 antibody-LRRK2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LRRK2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LRRK2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for LRRK2 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for LRRK2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any LRRK2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LRRK2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LRRK2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of LRRK2 elisa kit    LRRK2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS916685. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LRRK2. It may not necessarily be applicable to this product.
 NCBI GI #    146231954
 NCBI GeneID    66725
 NCBI Accession #    NP_080006.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_025730.3 [Other Products]
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 UniProt Primary Accession #    Q5S006 [Other Products]
 UniProt Secondary Accession #    Q8BWG7; Q8BZJ6; Q8CI84; Q8K062; E9QNJ2 [Other Products]
 UniProt Related Accession #    Q5S006 [Other Products]
 Molecular Weight    284,732 Da
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 NCBI Official Full Name    leucine-rich repeat serine/threonine-protein kinase 2
 NCBI Official Synonym Full Names    leucine-rich repeat kinase 2
 NCBI Official Symbol    Lrrk2 [Similar Products]
 NCBI Official Synonym Symbols   
Gm927; cI-46; AW561911; 4921513O20Rik; 9330188B09Rik; D630001M17Rik
[Similar Products]
 NCBI Protein Information    leucine-rich repeat serine/threonine-protein kinase 2
 UniProt Protein Name    Leucine-rich repeat serine/threonine-protein kinase 2
 Protein Family    Leucine-rich repeat serine/threonine-protein kinase
 UniProt Gene Name    Lrrk2 [Similar Products]
 UniProt Entry Name    LRRK2_MOUSE
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 UniProt Comments for LRRK2    LRRK2: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). May play a role in the etiology of Parkinson disease. May also have GTPase activity. Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Interacts with PARK2, PRDX3 and TPCN2. Expressed throughout the adult brain, but at a lower level than in heart and liver. Expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas. Defects in LRRK2 are the cause of Parkinson disease type 8 (PARK8). A slowly progressive neurodegenerative disorder characterized by bradykinesia, rigidity, resting tremor, postural instability, neuronal loss in the substantia nigra, and the presence of neurofibrillary MAPT (tau)-positive and Lewy bodies in some patients.

Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Kinase, protein; TKL group; LRRK family

Cellular Component: dendrite cytoplasm; Golgi apparatus; extracellular space; mitochondrion; lysosome; dendrite; terminal button; trans-Golgi network; inclusion body; cytosol; ribonucleoprotein complex; lipid raft; mitochondrial outer membrane; synaptic vesicle; membrane; cell soma; mitochondrial matrix; cytoplasm; mitochondrial inner membrane; synapse; intracellular; cytoplasmic vesicle; endosome; neuron projection; intracellular membrane-bound organelle; endoplasmic reticulum; perikaryon; cell projection; axon; mitochondrial membrane; plasma membrane; cell junction

Molecular Function: GTPase activity; tubulin binding; identical protein binding; clathrin binding; GTP-dependent protein kinase activity; Rho GTPase binding; protein homodimerization activity; GTP binding; nucleotide binding; actin binding; GTPase activator activity; protein kinase activity; transferase activity; MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; SNARE binding; protein kinase A binding; transferase activity, transferring phosphorus-containing groups; syntaxin-1 binding; kinase activity; glycoprotein binding; ATP binding

Biological Process: regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; positive regulation of protein binding; activation of MAPK activity; protein amino acid autophosphorylation; regulation of neuron maturation; determination of adult life span; protein amino acid phosphorylation; tangential migration from the subventricular zone to the olfactory bulb; negative regulation of protein amino acid phosphorylation; regulation of dopamine receptor signaling pathway; small GTPase mediated signal transduction; negative regulation of protein binding; regulation of mitochondrial depolarization; cell differentiation; Golgi organization and biogenesis; positive regulation of autophagy; neuromuscular junction development; positive regulation of dopamine receptor signaling pathway; olfactory bulb development; peptidyl-threonine phosphorylation; MAPKKK cascade; endocytosis; regulation of locomotion; peptidyl-serine phosphorylation; regulation of membrane potential; positive regulation of programmed cell death; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; intracellular distribution of mitochondria; autophagy; positive regulation of protein amino acid phosphorylation; response to oxidative stress; regulation of excitatory postsynaptic membrane potential; phosphorylation; neurite morphogenesis; positive regulation of GTPase activity
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 Research Articles on LRRK2    1. these results define a pathway for LRRK2 extracellular release, clarify one function of the LRRK2 14-3-3 interaction and provide a foundation for utilization of LRRK2 as a biomarker in clinical trials.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with LRRK2 elisa kitDiseases associated with LRRK2 elisa kit
 Products by Pathway  Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >649 publications with LRRK2 and Nervous System Diseases
 Brain Diseases Antibodies  >645 publications with LRRK2 and Brain Diseases
 Central Nervous System Diseases Antibodies  >641 publications with LRRK2 and Central Nervous System Diseases
 Movement Disorders Antibodies  >634 publications with LRRK2 and Movement Disorders
 Parkinsonian Disorders Antibodies  >621 publications with LRRK2 and Parkinsonian Disorders
 Neurodegenerative Diseases Antibodies  >619 publications with LRRK2 and Neurodegenerative Diseases
 Parkinson Disease Antibodies  >610 publications with LRRK2 and Parkinson Disease
 Tremor Antibodies  >51 publications with LRRK2 and Tremor
 Lewy Body Disease Antibodies  >43 publications with LRRK2 and Lewy Body Disease
 Disease Models, Animal Antibodies  >43 publications with LRRK2 and Disease Models, Animal
Organs/Tissues associated with LRRK2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >206 publications with LRRK2 and Brain
 Kidney Antibodies  >14 publications with LRRK2 and Kidney
 Spleen Antibodies  >6 publications with LRRK2 and Spleen
 Eye Antibodies  >5 publications with LRRK2 and Eye
 Skin Antibodies  >5 publications with LRRK2 and Skin
 Lung Antibodies  >4 publications with LRRK2 and Lung
 Bone Marrow Antibodies  >4 publications with LRRK2 and Bone Marrow
 Embryonic Tissue Antibodies  >3 publications with LRRK2 and Embryonic Tissue
 Lymph Node Antibodies  >1 publications with LRRK2 and Lymph Node
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