NP_001074540.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
44,400 Da
NCBI Official Full Name
lysocardiolipin acyltransferase 1
NCBI Official Synonym Full Names
lysocardiolipin acyltransferase 1
NCBI Official Synonym Symbols
Gm91; Lycat; Agpat8; Alcat1; AI181996 [Similar Products]
NCBI Protein Information
lysocardiolipin acyltransferase 1; acyl-CoA:lysocardiolipin acyltransferase 1
UniProt Protein Name
Lysocardiolipin acyltransferase 1
UniProt Synonym Protein Names
Acyl-CoA:lysocardiolipin acyltransferase 1
UniProt Synonym Gene Names
UniProt Entry Name
LCLT1_MOUSE
UniProt Comments for LCLAT1
AGPAT8: Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - ether lipid; Membrane protein, integral; Transferase; Secondary Metabolites Metabolism - limonene and pinene degradation; Membrane protein, multi-pass; EC 2.3.1.51; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Endoplasmic reticulum; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine
Cellular Component: membrane; endoplasmic reticulum; integral to membrane
Molecular Function: keto acid formate lyase activity; glucosaminyl-phosphotidylinositol O-acyltransferase activity; S-malonyltransferase activity; 3-hydroxybutyryl-CoA thiolase activity; S-acetyltransferase activity; O-octanoyltransferase activity; O-sinapoyltransferase activity; acyl-CoA N-acyltransferase activity; peptidyl-lysine N6-myristoyltransferase activity; palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; peptidyl-lysine N6-palmitoyltransferase activity; azetidine-2-carboxylic acid acetyltransferase activity; dihydrolipoamide branched chain acyltransferase activity; succinyltransferase activity; Ras palmitoyltransferase activity; palmitoyltransferase activity; C-acyltransferase activity; C-palmitoyltransferase activity; dihydrolipoamide S-acyltransferase activity; N-acetyltransferase activity; protein-cysteine S-acyltransferase activity; serine O-acyltransferase activity; O-palmitoyltransferase activity; malonyltransferase activity; octanoyltransferase activity; O-succinyltransferase activity; carnitine O-acyltransferase activity; sterol O-acyltransferase activity; 3-ketopimelyl-CoA thiolase activity; S-succinyltransferase activity; N-acyltransferase activity; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity; O-acyltransferase activity; N-palmitoyltransferase activity; acylglycerol O-acyltransferase activity; O-acetyltransferase activity; transferase activity; benzoyl acetate-CoA thiolase activity; sinapoyltransferase activity; S-acyltransferase activity; protein-cysteine S-myristoyltransferase activity; myristoyltransferase activity; N-succinyltransferase activity; acetyltransferase activity; transferase activity, transferring acyl groups; L-2-aminoadipate N-acetyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity
Biological Process: metabolic process; multicellular organismal development; lipid metabolic process; phospholipid biosynthetic process
Research Articles on LCLAT1
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Pathways associated with LCLAT1 elisa kit
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