NP_001239366.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,477 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase MGRN1 isoform 1
NCBI Official Synonym Full Names
mahogunin, ring finger 1
NCBI Official Synonym Symbols
md; nc; mKIAA0544; 2610042J20Rik [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase MGRN1; mahoganoid; mahogunin RING finger protein 1; probable E3 ubiquitin-protein ligase MGRN1
UniProt Protein Name
E3 ubiquitin-protein ligase MGRN1
UniProt Synonym Protein Names
Mahogunin RING finger protein 1
UniProt Synonym Gene Names
UniProt Entry Name
MGRN1_MOUSE
UniProt Comments for MGRN1
MGRN1: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system; EC 6.3.2.-
Cellular Component: membrane; early endosome; cytoplasm; plasma membrane; nucleus; endosome
Molecular Function: zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; ubiquitin-protein ligase activity; coenzyme F420-0 gamma-glutamyl ligase activity; ligase activity
Biological Process: protein monoubiquitination; protein polyubiquitination; negative regulation of G-protein coupled receptor protein signaling pathway; endosome to lysosome transport
Research Articles on MGRN1
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Pathways associated with MGRN1 elisa kit
Diseases associated with MGRN1 elisa kit
Organs/Tissues associated with MGRN1 elisa kit
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