NP_001003893.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,517 Da
NCBI Official Full Name
mannan-binding lectin serine protease 2 isoform 1
NCBI Official Synonym Full Names
mannan-binding lectin serine peptidase 2
NCBI Protein Information
mannan-binding lectin serine protease 2; MBL-associated serine protease 2; mannose-binding protein-associated serine protease 2
UniProt Protein Name
Mannan-binding lectin serine protease 2
UniProt Synonym Protein Names
MBL-associated serine protease 2; Mannose-binding protein-associated serine protease 2; MASP-2
UniProt Synonym Gene Names
UniProt Entry Name
MASP2_MOUSE
UniProt Comments for MASP2
MASP2: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.21.104
Cellular Component: extracellular region
Molecular Function: peptidase activity; protein binding; hydrolase activity; serine-type peptidase activity; metal ion binding; serine-type endopeptidase activity; complement component C4b binding; calcium ion binding; calcium-dependent protein binding; catalytic activity
Biological Process: immune system process; innate immune response; complement activation, lectin pathway; proteolysis; complement activation, classical pathway; complement activation
Research Articles on MASP2
Precautions
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Disclaimer
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Pathways associated with MASP2 elisa kit
Diseases associated with MASP2 elisa kit
Organs/Tissues associated with MASP2 elisa kit
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