NP_001076005.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
102,546 Da
NCBI Official Full Name
MKL/myocardin-like protein 1 isoform 2
NCBI Official Synonym Full Names
MKL (megakaryoblastic leukemia)/myocardin-like 1
NCBI Protein Information
MKL/myocardin-like protein 1; basic SAP and coiled-coil domains; myocardin-related transcription factor A; basic SAP coiled-coil transcription activator; megakaryoblastic leukemia (translocation) 1 homolog
UniProt Protein Name
MKL/myocardin-like protein 1
UniProt Synonym Protein Names
Basic SAP coiled-coil transcription activator; Megakaryoblastic leukemia 1 protein homolog; Myocardin-related transcription factor A; MRTF-A
UniProt Synonym Gene Names
UniProt Entry Name
MKL1_MOUSE
UniProt Comments for MKL1
MKL1: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation. Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2. Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.
Protein type: Transcription, coactivator/corepressor; Oncoprotein
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: actin monomer binding; protein binding; leucine zipper domain binding; transcription coactivator activity; actin binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity
Research Articles on MKL1
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Diseases associated with MKL1 elisa kit
Organs/Tissues associated with MKL1 elisa kit
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