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MEN1 elisa kit :: Mouse multiple endocrine neoplasia I ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9316506 MEN1 elisa kit
Unit / Price
48-Strip-Wells  /  $500 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,250 +4 FREE 8GB USB
10x96-Strip-Wells  /  $6,395 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

multiple endocrine neoplasia I (MEN1), ELISA Kit

 Also Known As   

Mouse Menin, MEN1 ELISA Kit

 Product Synonym Names    Mouse Menin (MEN1) ELISA kit; MEAI; SCG2; OTTHUMP00000070176; OTTHUMP00000070184; endocrine adenomatosis; multiple; menin; multiple endocrine neoplasia I
 Product Gene Name   

MEN1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O88559
 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MEN1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MEN1 purchase    MBS9316506 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the multiple endocrine neoplasia I (MEN1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MEN1. The ELISA analytical biochemical technique of the MBS9316506 kit is based on MEN1 antibody-MEN1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MEN1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MEN1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for MEN1. It may not necessarily be applicable to this product.
 NCBI GI #    270309147
 NCBI GeneID    17283
 NCBI Accession #    NP_001161960.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001168488.1 [Other Products]
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 UniProt Primary Accession #    O88559 [Other Products]
 UniProt Secondary Accession #    Q3U491; Q8CI72; Q91UZ7 [Other Products]
 UniProt Related Accession #    O88559 [Other Products]
 Molecular Weight    67,501 Da
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 NCBI Official Full Name    menin isoform a
 NCBI Official Synonym Full Names    multiple endocrine neoplasia 1
 NCBI Official Symbol    Men1 [Similar Products]
 NCBI Official Synonym Symbols   
AW045611
[Similar Products]
 NCBI Protein Information    menin
 UniProt Protein Name    Menin
 Protein Family    Menin
 UniProt Gene Name    Men1 [Similar Products]
 UniProt Entry Name    MEN1_MOUSE
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 UniProt Comments for MEN1    MEN1: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Interacts with POLR2A phosphorylated at 'Ser-5', but not with the unphosphorylated, nor 'Ser-2' phosphorylated POLR2A forms. Interacts with FANCD2 and DBF4. Interacts with JUND. Interacts with SMAD3, but not with SMAD2, nor SMAD4. Directly interacts with NFKB1, NFKB2 and RELA. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Cellular Component: nucleoplasm; histone methyltransferase complex; nuclear matrix; protein complex; cytoplasm; cytosol; chromatin; nucleus; cleavage furrow

Molecular Function: Y-form DNA binding; protein binding, bridging; protein binding; DNA binding; four-way junction DNA binding; sequence-specific DNA binding; double-stranded DNA binding; protein N-terminus binding; chromatin binding; histone-lysine N-methyltransferase activity

Biological Process: negative regulation of JNK cascade; maternal process involved in pregnancy; positive regulation of protein binding; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; palate development; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of protein amino acid phosphorylation; regulation of transcription, DNA-dependent; response to gamma radiation; hemopoiesis; negative regulation of osteoblast differentiation; cell cycle arrest; response to UV; negative regulation of epithelial cell proliferation; leukocyte homeostasis; ossification; positive regulation of histone methylation; transcription, DNA-dependent; negative regulation of transcription factor activity; negative regulation of cyclin-dependent protein kinase activity; MAPKKK cascade; positive regulation of transforming growth factor beta receptor signaling pathway; chromatin modification; negative regulation of organ growth; regulation of activin receptor signaling pathway; osteoblast development; embryonic skeletal morphogenesis; chromatin remodeling; histone methylation; positive regulation of osteoblast differentiation; negative regulation of telomerase activity; embryonic development; positive regulation of cell division; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell differentiation; response to DNA damage stimulus; osteoblast fate commitment
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 Research Articles on MEN1    1. Loss of MEN1 expression is associated with insulinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MEN1 elisa kitPathways associated with MEN1 elisa kit
 Reference Product  PubMed Publications
 Jund elisa kit  >47 publications with MEN1 and Jund
 Prl elisa kit  >30 publications with MEN1 and Prl
 Smad3 elisa kit  >16 publications with MEN1 and Smad3
 Mll1 elisa kit  >14 publications with MEN1 and Mll1
 Mll2 elisa kit  >12 publications with MEN1 and Mll2
 Smad4 elisa kit  >6 publications with MEN1 and Smad4
 Fancd2 elisa kit  >4 publications with MEN1 and Fancd2
 Smad2 elisa kit  >1 publications with MEN1 and Smad2
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies  RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram
 SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway antibodies  SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway Diagram
Diseases associated with MEN1 elisa kitOrgans/Tissues associated with MEN1 elisa kit
 Disease Name  Pubmed Publications
 Multiple Endocrine Neoplasia Type 1 Antibodies  >2013 publications with MEN1 and Multiple Endocrine Neoplasia Type 1
 Pancreatic Neoplasms Antibodies  >822 publications with MEN1 and Pancreatic Neoplasms
 Neuroendocrine Tumors Antibodies  >613 publications with MEN1 and Neuroendocrine Tumors
 Adenocarcinoma Antibodies  >513 publications with MEN1 and Adenocarcinoma
 Nervous System Diseases Antibodies  >431 publications with MEN1 and Nervous System Diseases
 Gastrinoma Antibodies  >302 publications with MEN1 and Gastrinoma
 Hyperplasia Antibodies  >255 publications with MEN1 and Hyperplasia
 Liver Neoplasms Antibodies  >165 publications with MEN1 and Liver Neoplasms
 Kidney Diseases Antibodies  >125 publications with MEN1 and Kidney Diseases
 Musculoskeletal Diseases Antibodies  >120 publications with MEN1 and Musculoskeletal Diseases
 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >483 publications with MEN1 and Other
 Pancreas Antibodies  >396 publications with MEN1 and Pancreas
 Liver Antibodies  >169 publications with MEN1 and Liver
 Kidney Antibodies  >131 publications with MEN1 and Kidney
 Stomach Antibodies  >121 publications with MEN1 and Stomach
 Bone Antibodies  >87 publications with MEN1 and Bone
 Brain Antibodies  >73 publications with MEN1 and Brain
 Thymus Antibodies  >71 publications with MEN1 and Thymus
 Lung Antibodies  >69 publications with MEN1 and Lung
 Skin Antibodies  >45 publications with MEN1 and Skin
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