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PITX3 elisa kit :: Mouse paired-like homeodomain 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9321689 PITX3 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

paired-like homeodomain 3 (PITX3), ELISA Kit

 Also Known As   

Mouse Pituitary homeobox 3, PITX3 ELISA Kit

 Product Synonym Names    Mouse Pituitary homeobox 3 (PITX3) ELISA kit; CTPP4; MGC12766; PTX3; homeobox protein PITX3; paired-like homeodomain 3
 Product Gene Name   

PITX3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O35160
 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PITX3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PITX3 purchase    MBS9321689 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the paired-like homeodomain 3 (PITX3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PITX3. The ELISA analytical biochemical technique of the MBS9321689 kit is based on PITX3 antibody-PITX3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PITX3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PITX3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PITX3. It may not necessarily be applicable to this product.
 NCBI GI #    6679341
 NCBI GeneID    18742
 NCBI Accession #    NP_032878.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_008852.4 [Other Products]
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 UniProt Primary Accession #    O35160 [Other Products]
 UniProt Secondary Accession #    Q0VB03 [Other Products]
 UniProt Related Accession #    O35160 [Other Products]
 Molecular Weight    31,715 Da
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 NCBI Official Full Name    pituitary homeobox 3
 NCBI Official Synonym Full Names    paired-like homeodomain transcription factor 3
 NCBI Official Symbol    Pitx3 [Similar Products]
 NCBI Official Synonym Symbols   
ak; Ptx3
[Similar Products]
 NCBI Protein Information    pituitary homeobox 3; aphakia; homeobox protein PITX3; Pituitary homeobox 3 (Homeobox protein PITX3)
 UniProt Protein Name    Pituitary homeobox 3
 UniProt Synonym Protein Names   
Homeobox protein PITX3; Paired-like homeodomain transcription factor 3
 Protein Family    Pituitary homeobox
 UniProt Gene Name    Pitx3 [Similar Products]
 UniProt Entry Name    PITX3_MOUSE
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 UniProt Comments for PITX3    PITX3: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1- mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle. Defects in PITX3 are a cause of cataract autosomal dominant (ADC). Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract is the most common treatable cause of visual disability in childhood. Defects in PITX3 are a cause of anterior segment mesenchymal dysgenesis (ASMD); also known as anterior segment ocular dysgenesis (ASOD). ASMD consists of a range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Mature anterior segment anomalies are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis. Defects in PITX3 are the cause of cataract posterior polar type 4 (CTPP4). A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity. Some patients affected by cataract posterior polar type 4 can present a severe phenotype including microphthalmia and neurological dysfunction. Belongs to the paired homeobox family. Bicoid subfamily.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Cellular Component: nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: lens development in camera-type eye; transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of gene expression; multicellular organismal development; positive regulation of transcription, DNA-dependent; midbrain development; neuron development; locomotory behavior; lens morphogenesis in camera-type eye; positive regulation of transcription from RNA polymerase II promoter
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 Research Articles on PITX3    1. During fetal myogenesis, Pitx2/3 control this redox state through the regulation of Nrf1 and of antioxidant pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PITX3 elisa kitDiseases associated with PITX3 elisa kit
 Products by Pathway  Pathway Diagram
 Dopminergic Neurogenesis Pathway antibodies  Dopminergic Neurogenesis Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >52 publications with PITX3 and Nervous System Diseases
 Brain Diseases Antibodies  >42 publications with PITX3 and Brain Diseases
 Congenital Abnormalities Antibodies  >42 publications with PITX3 and Congenital Abnormalities
 Movement Disorders Antibodies  >41 publications with PITX3 and Movement Disorders
 Basal Ganglia Diseases Antibodies  >38 publications with PITX3 and Basal Ganglia Diseases
 Parkinsonian Disorders Antibodies  >38 publications with PITX3 and Parkinsonian Disorders
 Parkinson Disease Antibodies  >37 publications with PITX3 and Parkinson Disease
 Eye Abnormalities Antibodies  >27 publications with PITX3 and Eye Abnormalities
 Cataract Antibodies  >26 publications with PITX3 and Cataract
 Disease Models, Animal Antibodies  >21 publications with PITX3 and Disease Models, Animal
Organs/Tissues associated with PITX3 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >57 publications with PITX3 and Eye
 Embryonic Tissue Antibodies  >37 publications with PITX3 and Embryonic Tissue
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