NP_062285.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
147,688 Da
NCBI Official Full Name
periaxin isoform S
NCBI Official Synonym Full Names
periaxin
NCBI Official Synonym Symbols
NCBI Protein Information
periaxin
UniProt Protein Name
Periaxin
UniProt Entry Name
PRAX_MOUSE
UniProt Comments for PRX
PRX: Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition. Defects in PRX are a cause of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie- Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. Belongs to the periaxin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Cellular Component: membrane; cytoplasm; plasma membrane; nucleus; myelin sheath
Molecular Function: protein binding
Biological Process: regulation of RNA splicing
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Diseases associated with PRX elisa kit
Organs/Tissues associated with PRX elisa kit
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