NP_067426.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
11,566 Da
NCBI Official Full Name
phorbol-12-myristate-13-acetate-induced protein 1
NCBI Official Synonym Full Names
phorbol-12-myristate-13-acetate-induced protein 1
NCBI Official Synonym Symbols
NCBI Protein Information
phorbol-12-myristate-13-acetate-induced protein 1; protein Noxa
UniProt Protein Name
Phorbol-12-myristate-13-acetate-induced protein 1
UniProt Synonym Protein Names
Protein Noxa
UniProt Synonym Gene Names
UniProt Entry Name
APR_MOUSE
UniProt Comments for PMAIP1
NOXA: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1. Interacts with MCL1, BCL2A1 and BAX. Up-regulated by p53/TP53, phorbol esters, double- stranded RNA, IFNB1/IFN-beta and viruses. Highly expressed in adult T-cell leukemia cell line. Belongs to the PMAIP1 family.
Protein type: Mitochondrial; Apoptosis
Cellular Component: mitochondrion; intracellular
Molecular Function: protein binding
Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of apoptosis; apoptosis; regulation of apoptosis; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of fibroblast proliferation; positive regulation of neuron apoptosis; T cell homeostasis; positive regulation of DNA damage response, signal transduction by p53 class mediator; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to DNA damage stimulus; response to X-ray; response to UV
Research Articles on PMAIP1
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Products associated with PMAIP1 elisa kit
Pathways associated with PMAIP1 elisa kit
Diseases associated with PMAIP1 elisa kit
Organs/Tissues associated with PMAIP1 elisa kit
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