NP_061346.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,830 Da
NCBI Official Full Name
phosphatidylethanolamine-binding protein 1
NCBI Official Synonym Full Names
phosphatidylethanolamine binding protein 1
NCBI Protein Information
phosphatidylethanolamine-binding protein 1; HCNPpp; PEBP-1; Raf-1 inhibitor protein; Raf-1 kinase inhibitor protein
UniProt Protein Name
Phosphatidylethanolamine-binding protein 1
UniProt Synonym Protein Names
HCNPppCleaved into the following chain:Hippocampal cholinergic neurostimulating peptide; HCNP
UniProt Synonym Gene Names
UniProt Entry Name
PEBP1_MOUSE
UniProt Comments for PEBP1
RKIP: a metastasis suppressor that regulates extracellular matrix remodeling and tumor survival. Binds to and inhibits Raf-1. Phosphorylation by classic and atypical but not novel PKC isoforms dissociates this complex, relieving inhibition of the Raf/MAP kinase signaling cascade. Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. Cleaved into hippocampal cholinergic neurostimulating peptide (HCMP) that appears to be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Expressed in brain. Increased expression in aged senescence-accelerated mice.
Protein type: Lipid-binding; Protein kinase, regulatory subunit
Cellular Component: Golgi apparatus; extracellular space; synaptic vesicle; mitochondrial outer membrane; neuron projection; cell surface; mitochondrion; rough endoplasmic reticulum; cell soma; apical part of cell; cytoplasm; nerve terminal; nucleus; myelin sheath
Molecular Function: serine-type endopeptidase inhibitor activity; enzyme binding; protease inhibitor activity; nucleotide binding; mitogen-activated protein kinase binding; lipid binding; protein kinase binding; kinase binding; ATP binding; receptor binding
Biological Process: positive regulation of mitosis; negative regulation of protein amino acid phosphorylation; negative regulation of MAPKKK cascade; regulation of neurotransmitter levels; MAPKKK cascade; negative regulation of peptidase activity; sperm capacitation; regulation of the force of heart contraction
Research Articles on PEBP1
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Pathways associated with PEBP1 elisa kit
Diseases associated with PEBP1 elisa kit
Organs/Tissues associated with PEBP1 elisa kit
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