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PLAT elisa kit :: Mouse plasminogen activator, tissue ELISA Kit

Scan QR to view Datasheet Catalog #    MBS704245
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

plasminogen activator, tissue (PLAT), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Tissue-type Plasiminogen Actilyse, t-PA ELISA Kit

 Product Synonym Names    Mouse Tissue-type Plasiminogen Actilyse; t-PA ELISA Kit; DKFZp686I03148; T-PA; TPA; alteplase; plasminogen activator; tissue type; reteplase; t-plasminogen activator; tissue plasminogen activator (t-PA) ; plasminogen activator; tissue
 Product Gene Name   

PLAT elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS704245 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for P11214
 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of mouse t-PA. No significant cross-reactivity or interference between mouse t-PA and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Detection Range    125 pg/ml -8000 pg/mL
 Sensitivity    <31.25 pg/mL
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PLAT elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PLAT purchase    MBS704245 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the plasminogen activator, tissue (PLAT) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 125 pg/ml -8000 pg/mL in biological research samples containing PLAT, with an estimated sensitivity of <31.25 pg/mL. The ELISA analytical biochemical technique of the MBS704245 kit is based on PLAT antibody-PLAT antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PLAT antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PLAT. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PLAT elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for t-PA has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any t-PA present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for t-PA is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of t-PA bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of PLAT elisa kit    PLAT elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS704245. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PLAT. It may not necessarily be applicable to this product.
 NCBI GI #    170763477
 NCBI GeneID    18791
 NCBI Accession #    NP_032898.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_008872.2 [Other Products]
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 UniProt Primary Accession #    P11214 [Other Products]
 UniProt Secondary Accession #    Q6P7U0; Q91VP2 [Other Products]
 UniProt Related Accession #    P11214 [Other Products]
 Molecular Weight    63,097 Da
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 NCBI Official Full Name    tissue-type plasminogen activator preproprotein
 NCBI Official Synonym Full Names    plasminogen activator, tissue
 NCBI Official Symbol    Plat [Similar Products]
 NCBI Official Synonym Symbols   
tPA; AU020998; AW212668; D8Ertd2e
[Similar Products]
 NCBI Protein Information    tissue-type plasminogen activator; t-plasminogen activator
 UniProt Protein Name    Tissue-type plasminogen activator
 Protein Family    Tissue-type plasminogen activator
 UniProt Gene Name    Plat [Similar Products]
 UniProt Synonym Gene Names    t-PA; t-plasminogen activator; tPA [Similar Products]
 UniProt Entry Name    TPA_MOUSE
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 NCBI Summary for PLAT    This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]
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 UniProt Comments for PLAT    Function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events.

Catalytic activity: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.

Enzyme regulation: Inhibited by SERPINA5
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 Research Articles on PLAT    1. Endogenously released tPA promotes neutrophil transmigration to reperfused tissue via proteolytic activation of plasmin and gelatinases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLAT elisa kitPathways associated with PLAT elisa kit
 Reference Product  PubMed Publications
 FLNA elisa kit  >12 publications with PLAT and FLNA
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By PDGF Pathway antibodies  Signaling By PDGF Pathway Diagram
Diseases associated with PLAT elisa kitOrgans/Tissues associated with PLAT elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >34 publications with PLAT and Inflammation
 Atherosclerosis Antibodies  >25 publications with PLAT and Atherosclerosis
 Arterial Occlusive Diseases Antibodies  >24 publications with PLAT and Arterial Occlusive Diseases
 Thrombosis Antibodies  >19 publications with PLAT and Thrombosis
 Necrosis Antibodies  >17 publications with PLAT and Necrosis
 Cerebral Infarction Antibodies  >15 publications with PLAT and Cerebral Infarction
 Myocardial Infarction Antibodies  >14 publications with PLAT and Myocardial Infarction
 Stroke Antibodies  >14 publications with PLAT and Stroke
 Hypertension Antibodies  >14 publications with PLAT and Hypertension
 Embolism and Thrombosis Antibodies  >10 publications with PLAT and Embolism and Thrombosis
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with PLAT and Bone
 Connective Tissue Antibodies  >4 publications with PLAT and Connective Tissue
 Heart Antibodies  >3 publications with PLAT and Heart
 Muscle Antibodies  >3 publications with PLAT and Muscle
 Brain Antibodies  >3 publications with PLAT and Brain
 Vascular Antibodies  >2 publications with PLAT and Vascular
 Embryonic Tissue Antibodies  >2 publications with PLAT and Embryonic Tissue
 Ear Antibodies  >1 publications with PLAT and Ear
 Kidney Antibodies  >1 publications with PLAT and Kidney
 Umbilical Cord Antibodies  >1 publications with PLAT and Umbilical Cord
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