NP_033114.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
194,110 Da
NCBI Official Full Name
DNA-directed RNA polymerase I subunit RPA1
NCBI Official Synonym Full Names
polymerase (RNA) I polypeptide A
NCBI Official Synonym Symbols
mRPA1; 194kDa; RPA194; Rpo1-4; 3010014K16Rik [Similar Products]
NCBI Protein Information
DNA-directed RNA polymerase I subunit RPA1; RNA polymerase I subunit A1; RNA polymerase I 194 kDa subunit; RNA polymerase 1-4 (194 kDa subunit); DNA-directed RNA polymerase I subunit A; DNA-directed RNA polymerase I largest subunit
UniProt Protein Name
DNA-directed RNA polymerase I subunit RPA1
UniProt Synonym Protein Names
DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RPA194
UniProt Synonym Gene Names
UniProt Entry Name
RPA1_MOUSE
UniProt Comments for POLR1A
POLR1A: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Belongs to the RNA polymerase beta' chain family.
Protein type: Nucleolus; Transcription initiation complex; Nucleotide Metabolism - pyrimidine; Transferase; Nucleotide Metabolism - purine; EC 2.7.7.6
Cellular Component: cytoplasm; nucleolus; nucleus; DNA-directed RNA polymerase I complex
Molecular Function: transferase activity; protein binding; DNA binding; zinc ion binding; DNA-directed RNA polymerase activity; metal ion binding; nucleotidyltransferase activity
Biological Process: transcription, DNA-dependent; rRNA transcription
Research Articles on POLR1A
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Pathways associated with POLR1A elisa kit
Organs/Tissues associated with POLR1A elisa kit
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