NP_035328.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
69,013 Da
NCBI Official Full Name
prostaglandin G/H synthase 2
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 2
NCBI Official Synonym Symbols
COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2 [Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 2; PES-2; PHS II; gripghs; PGH synthase 2; cyclooxygenase 2; cyclooxygenase-2; prostaglandin H2 synthase 2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73
UniProt Protein Name
Prostaglandin G/H synthase 2
UniProt Synonym Protein Names
Cyclooxygenase-2; COX-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; Macrophage activation-associated marker protein P71/73; PES-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2; TIS10 protein
UniProt Synonym Gene Names
UniProt Entry Name
PGH2_MOUSE
UniProt Comments for PTGS2
Function: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.5 PublicationsManual assertion based on experiment in:Ref.10
Catalytic activity: Arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.4 PublicationsManual assertion based on experiment in:Ref.15
Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit.3 PublicationsManual assertion based on experiment in:Ref.13
Enzyme regulation: Inhibited by the nonsteroidal anti-inflammatory drugs aspirin, naproxen, diclofenac, meclofenamic acid, indomethacin and their analogs.2 PublicationsManual assertion based on experiment in:Ref.15
Research Articles on PTGS2
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Products associated with PTGS2 elisa kit
Pathways associated with PTGS2 elisa kit
Diseases associated with PTGS2 elisa kit
Organs/Tissues associated with PTGS2 elisa kit
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