Q9R144.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
50,476 Da
NCBI Official Full Name
Protein arginine N-methyltransferase 2
NCBI Official Synonym Full Names
protein arginine N-methyltransferase 2
NCBI Protein Information
protein arginine N-methyltransferase 2; histone-arginine N-methyltransferase PRMT2; heterogeneous nuclear ribonucleoprotein methyltransferase-like 1
UniProt Protein Name
Protein arginine N-methyltransferase 2
UniProt Synonym Protein Names
Histone-arginine N-methyltransferase PRMT2 (EC:2.1.1.125)
UniProt Synonym Gene Names
UniProt Entry Name
ANM2_MOUSE
UniProt Comments for PRMT2
PRMT2: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Methyltransferase; Nuclear receptor co-regulator; Methyltransferase, protein arginine; EC 2.1.1.125
Cellular Component: nucleoplasm; Rb-E2F complex; cytoplasm; nucleus; cytosol
Molecular Function: methyltransferase activity; protein homodimerization activity; trimethylamine methyltransferase activity; monomethylamine methyltransferase activity; RNA methyltransferase activity; tRNA (cytosine)-methyltransferase activity; rRNA (cytosine-C5-967)-methyltransferase activity; rRNA (uridine) methyltransferase activity; N-methyltransferase activity; tRNA (guanine) methyltransferase activity; rRNA (adenine-N6,N6-)-dimethyltransferase activity; selenocysteine methyltransferase activity; arginine N-methyltransferase activity; methanol-specific methylcobalamin:coenzyme M methyltransferase activity; protein-arginine N-methyltransferase activity; tRNA (guanine-N2-)-methyltransferase activity; dimethylamine methyltransferase activity; protein methyltransferase activity; 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity; transferase activity; hydroxyneurosporene-O-methyltransferase activity; rRNA (uridine-2'-O-)-methyltransferase activity; tRNA (uracil) methyltransferase activity; rRNA (adenine) methyltransferase activity; C-methyltransferase activity; thyroid hormone receptor binding; cobalt-precorrin-6B C5-methyltransferase activity; cobalt-precorrin-3 C17-methyltransferase activity; 1-phenanthrol methyltransferase activity; retinoic acid receptor binding; transcription coactivator activity; S-methyltransferase activity; lysine N-methyltransferase activity; DNA-methyltransferase activity; tRNA (cytosine-5-)-methyltransferase activity; C-terminal protein carboxyl methyltransferase activity; tRNA (adenine)-methyltransferase activity; androgen receptor binding; rRNA (cytosine) methyltransferase activity; cobalt-precorrin-7 C15-methyltransferase activity; protein-arginine N5-methyltransferase activity; progesterone receptor binding; rRNA methyltransferase activity; histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; peroxisome proliferator activated receptor binding; beta-catenin binding; histone-arginine N-methyltransferase activity; protein-leucine O-methyltransferase activity; demethylmenaquinone methyltransferase activity; rRNA (adenine-N6-)-methyltransferase activity; tRNA methyltransferase activity; rRNA (guanine) methyltransferase activity; methylarsonite methyltransferase activity; mRNA methyltransferase activity; protein binding; methylamine-specific methylcobalamin:coenzyme M methyltransferase activity; tRNA (guanine-N1-)-methyltransferase activity; cobalt-precorrin-5B C1-methyltransferase activity; protein-lysine N-methyltransferase activity; estrogen receptor binding; O-methyltransferase activity; tRNA (adenine-N1-)-methyltransferase activity; tRNA (adenine-57, 58-N(1)-) methyltransferase activity
Biological Process: methylation; histone methylation; developmental cell growth; protein amino acid methylation; positive regulation of apoptosis; inhibition of NF-kappaB transcription factor; negative regulation of transcription factor activity; regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of transcription, DNA-dependent; response to hypoxia; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; peptidyl-arginine N-methylation; negative regulation of transcription, DNA-dependent; leptin-mediated signaling pathway
Research Articles on PRMT2
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Pathways associated with PRMT2 elisa kit
Organs/Tissues associated with PRMT2 elisa kit
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