NP_659044.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
32,373 Da
NCBI Official Full Name
pyrroline-5-carboxylate reductase 1, mitochondrial
NCBI Official Synonym Full Names
pyrroline-5-carboxylate reductase 1
NCBI Protein Information
pyrroline-5-carboxylate reductase 1, mitochondrial; P5CR 1; P5C reductase 1
UniProt Protein Name
Pyrroline-5-carboxylate reductase 1, mitochondrial
UniProt Synonym Gene Names
UniProt Entry Name
P5CR1_MOUSE
UniProt Comments for PYCR1
PYCR1: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Defects in PYCR1 are the cause of cutis laxa autosomal recessive type 2B (ARCL2B). A multisystem disorder characterized by the appearance of premature aging, wrinkled and lax skin with reduced elasticity, joint laxity, craniofacial dysmorphic features, intrauterine growth retardation with some degree of postnatal growth deficiency, and developmental delay. Defects in PYCR1 are the cause of cutis laxa, autosomal recessive, type 3B (ARCL3B). ARCL3B is a disorder characterized by an aged appearance with distinctive facial features, sparse hair, ophthalmologic abnormalities, intrauterine growth retardation, and cutis laxa. Belongs to the pyrroline-5-carboxylate reductase family.
Protein type: Mitochondrial; Oxidoreductase; Amino Acid Metabolism - arginine and proline; EC 1.5.1.2
Cellular Component: mitochondrion
Molecular Function: identical protein binding; pyrroline-5-carboxylate reductase activity; oxidoreductase activity
Biological Process: regulation of mitochondrial membrane potential; proline biosynthetic process; amino acid biosynthetic process
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Pathways associated with PYCR1 elisa kit
Diseases associated with PYCR1 elisa kit
Organs/Tissues associated with PYCR1 elisa kit
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