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SIK1 elisa kit :: Mouse salt-inducible kinase 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9323388 SIK1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

salt-inducible kinase 1 (SIK1), ELISA Kit

 Also Known As   

Mouse Serine/threonine-protein kinase SIK1, SIK1 ELISA Kit

 Product Synonym Names    Mouse Serine/threonine-protein kinase SIK1 (SIK1) ELISA kit; MSK; SIK; SNF1LK; SNF1-like kinase; myocardial SNF1-like kinase; serine/threonine protein kinase; salt-inducible kinase 1
 Product Gene Name   

SIK1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for Q60670
 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SIK1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SIK1 purchase    MBS9323388 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the salt-inducible kinase 1 (SIK1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SIK1. The ELISA analytical biochemical technique of the MBS9323388 kit is based on SIK1 antibody-SIK1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SIK1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SIK1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SIK1. It may not necessarily be applicable to this product.
 NCBI GI #    110815830
 NCBI GeneID    17691
 NCBI Accession #    NP_034961.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_010831.2 [Other Products]
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 UniProt Primary Accession #    Q60670 [Other Products]
 UniProt Secondary Accession #    Q3UR46 [Other Products]
 UniProt Related Accession #    Q60670 [Other Products]
 Molecular Weight    85,115 Da
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 NCBI Official Full Name    serine/threonine-protein kinase SIK1
 NCBI Official Synonym Full Names    salt inducible kinase 1
 NCBI Official Symbol    Sik1 [Similar Products]
 NCBI Official Synonym Symbols   
Msk; Sik; Snf1lk
[Similar Products]
 NCBI Protein Information    serine/threonine-protein kinase SIK1; SIK-1; HRT-20; SNF1-like kinase; salt-inducible kinase 1; myocardial SNF1-like kinase; salt-inducible protein kinase 1; serine/threonine-protein kinase SNF1LK; serine/threonine-protein kinase SNF1-like kinase 1; Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase)
 UniProt Protein Name    Serine/threonine-protein kinase SIK1
 UniProt Synonym Protein Names   
HRT-20; Myocardial SNF1-like kinase; Salt-inducible kinase 1; SIK-1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK
 Protein Family    Serine/threonine-protein kinase
 UniProt Gene Name    Sik1 [Similar Products]
 UniProt Synonym Gene Names    Msk; Sik; Snf1lk; SIK-1; Serine/threonine-protein kinase SNF1LK [Similar Products]
 UniProt Entry Name    SIK1_MOUSE
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 UniProt Comments for SIK1    SIK: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. Interacts with ATP1A1. Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ. Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the reversible sodium/calcium exchanger. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.

Protein type: EC 2.7.11.1; Tumor suppressor; Motility/polarity/chemotaxis; Protein kinase, CAMK; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; QIK subfamily

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; metal ion binding; histone deacetylase binding; cAMP response element binding protein binding; transferase activity, transferring phosphorus-containing groups; magnesium ion binding; nucleotide binding; kinase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: multicellular organismal development; regulation of mitotic cell cycle; rhythmic process; negative regulation of transcription from RNA polymerase II promoter; regulation of sodium ion transport; cell cycle; protein amino acid phosphorylation; cardiac muscle cell differentiation; anoikis; entrainment of circadian clock by photoperiod; negative regulation of gluconeogenesis; inhibition of CREB transcription factor; cell differentiation; phosphorylation
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 Research Articles on SIK1    1. SIK1 and SIK3 negatively regulate TLR4-mediated signaling through the interruption of TAB2-TRAF6 complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with SIK1 elisa kitOrgans/Tissues associated with SIK1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with SIK1 and Neoplasms
 Cardiovascular Diseases Antibodies  >5 publications with SIK1 and Cardiovascular Diseases
 Hypertension Antibodies  >4 publications with SIK1 and Hypertension
 Breast Neoplasms Antibodies  >3 publications with SIK1 and Breast Neoplasms
 Fatty Liver Antibodies  >2 publications with SIK1 and Fatty Liver
 Hypertrophy Antibodies  >2 publications with SIK1 and Hypertrophy
 Kidney Diseases Antibodies  >2 publications with SIK1 and Kidney Diseases
 Lung Neoplasms Antibodies  >1 publications with SIK1 and Lung Neoplasms
 Renal Insufficiency Antibodies  >1 publications with SIK1 and Renal Insufficiency
 Heart Diseases Antibodies  >1 publications with SIK1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with SIK1 and Brain
 Kidney Antibodies  >7 publications with SIK1 and Kidney
 Heart Antibodies  >5 publications with SIK1 and Heart
 Liver Antibodies  >5 publications with SIK1 and Liver
 Lung Antibodies  >3 publications with SIK1 and Lung
 Connective Tissue Antibodies  >3 publications with SIK1 and Connective Tissue
 Inner Ear Antibodies  >1 publications with SIK1 and Inner Ear
 Embryonic Tissue Antibodies  >1 publications with SIK1 and Embryonic Tissue
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