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SIRT6 elisa kit :: Mouse sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9320123 SIRT6 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) (SIRT6), ELISA Kit

 Also Known As   

Mouse NAD-dependent deacetylase sirtuin-6, SIRT6 ELISA Kit

 Product Synonym Names    Mouse NAD-dependent deacetylase sirtuin-6 (SIRT6) ELISA kit; SIR2L6; sir2-related protein type 6; sirtuin 6; sirtuin type 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
 Product Gene Name   

SIRT6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for P59941
 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SIRT6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SIRT6 purchase    MBS9320123 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) (SIRT6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SIRT6. The ELISA analytical biochemical technique of the MBS9320123 kit is based on SIRT6 antibody-SIRT6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SIRT6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SIRT6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SIRT6. It may not necessarily be applicable to this product.
 NCBI GI #    31712018
 NCBI GeneID    50721
 NCBI Accession #    NP_853617.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_181586.3 [Other Products]
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 UniProt Primary Accession #    P59941 [Other Products]
 UniProt Related Accession #    P59941 [Other Products]
 Molecular Weight    36,920 Da
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 NCBI Official Full Name    NAD-dependent protein deacetylase sirtuin-6 isoform 1
 NCBI Official Synonym Full Names    sirtuin 6
 NCBI Official Symbol    Sirt6 [Similar Products]
 NCBI Official Synonym Symbols   
Sir2l6; AI043036; 2810449N18Rik
[Similar Products]
 NCBI Protein Information    NAD-dependent protein deacetylase sirtuin-6; SIR2-like protein 6; regulatory protein SIR2 homolog 6; NAD-dependent deacetylase sirtuin-6
 UniProt Protein Name    NAD-dependent protein deacetylase sirtuin-6
 UniProt Synonym Protein Names   
Regulatory protein SIR2 homolog 6; SIR2-like protein 6
 Protein Family    NAD-dependent protein deacetylase
 UniProt Gene Name    Sirt6 [Similar Products]
 UniProt Synonym Gene Names    Sir2l6 [Similar Products]
 UniProt Entry Name    SIR6_MOUSE
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 UniProt Comments for SIRT6    SIRT6: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC; Transferase; Deacetylase; EC 3.5.1.-

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear telomeric heterochromatin; nucleus

Molecular Function: (3,5-dichlorophenylurea)acetate amidohydrolase activity; NAD(P)+-protein-arginine ADP-ribosyltransferase activity; hydrolase activity; metal ion binding; protein deacetylase activity; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; N-acetylgalactosamine-6-phosphate deacetylase activity; N2-acetyl-L-lysine deacetylase activity; iprodione amidohydrolase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); indoleacetamide hydrolase activity; protein N-terminal asparagine amidohydrolase activity; chromatin binding; histone deacetylase activity; O-succinylbenzoate synthase activity

Biological Process: protein amino acid ADP-ribosylation
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 Research Articles on SIRT6    1. Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with SIRT6 elisa kitOrgans/Tissues associated with SIRT6 elisa kit
 Disease Name  Pubmed Publications
 Mitochondrial Diseases Antibodies  >4 publications with SIRT6 and Mitochondrial Diseases
 Atherosclerosis Antibodies  >3 publications with SIRT6 and Atherosclerosis
 Necrosis Antibodies  >2 publications with SIRT6 and Necrosis
 Ischemia Antibodies  >2 publications with SIRT6 and Ischemia
 Infertility Antibodies  >1 publications with SIRT6 and Infertility
 Uterine Diseases Antibodies  >1 publications with SIRT6 and Uterine Diseases
 Hyperinsulinism Antibodies  >1 publications with SIRT6 and Hyperinsulinism
 Carotid Artery Diseases Antibodies  >1 publications with SIRT6 and Carotid Artery Diseases
 Breast Neoplasms Antibodies  >1 publications with SIRT6 and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with SIRT6 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >5 publications with SIRT6 and Heart
 Brain Antibodies  >4 publications with SIRT6 and Brain
 Liver Antibodies  >4 publications with SIRT6 and Liver
 Embryonic Tissue Antibodies  >2 publications with SIRT6 and Embryonic Tissue
 Ovary Antibodies  >1 publications with SIRT6 and Ovary
 Skin Antibodies  >1 publications with SIRT6 and Skin
 Kidney Antibodies  >1 publications with SIRT6 and Kidney
 Bone Antibodies  >1 publications with SIRT6 and Bone
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