NP_613050.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,151 Da
NCBI Official Full Name
maspardin
NCBI Official Synonym Full Names
spastic paraplegia 21 homolog (human)
NCBI Official Synonym Symbols
MAST; ACP33; GL010; BM-019; C78576; D9Wsu18e [Similar Products]
NCBI Protein Information
maspardin; acid cluster protein 33; spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog
UniProt Protein Name
Maspardin
UniProt Synonym Protein Names
Acid cluster protein 33; Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog
UniProt Entry Name
SPG21_MOUSE
UniProt Comments for SPG21
SPG21: May play a role as a negative regulatory factor in CD4- dependent T-cell activation. Defects in SPG21 are the cause of spastic paraplegia autosomal recessive type 21 (SPG21); also known as Mast syndrome. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG21 is associated with dementia and other central nervous system abnormalities. Subtle childhood abnormalities may be present, but the main features develop in early adulthood. The disease is slowly progressive, and cerebellar and extrapyramidal signs are also found in patients with advanced disease. Patients have a thin corpus callosum and white-matter abnormalities. Belongs to the AB hydrolase superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Cellular Component: nucleoplasm; trans-Golgi network transport vesicle; cytoplasm; cytosol; nucleus
Molecular Function: CD4 receptor binding
Research Articles on SPG21
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Diseases associated with SPG21 elisa kit
Organs/Tissues associated with SPG21 elisa kit
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