Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow ELISA Kit rightarrow SOCS-1 rightarrow Mouse SOCS-1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Thioredoxin Reductase 1 (TXNRD1) Antibody
 • beta2 Microglobulin (beta2-MG) ELISA Kit
 • Cystatin C, Recombinant (CST3) Recombinant Protein
 • Copeptin (CPP) ELISA Kit
 • TXNDC5 Antibody
 • PTGER2 - EP2 Antibody
 • Cytokeratin 5 (KRT5) Antibody
 • GST Recombinant Protein
 • ADP-ribosylation factor-like protein 2 (ARL2) Antibody
 • Calcium Sensing Receptor (CASR) ELISA Kit
 • Deoxyribodipyrimidine photo-lyase (phr) Recombinant Protein
 • HCK Antibody
 • HMGCR Antibody
 • Cellular Fibronectin (CFN) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SOCS-1 elisa kit :: Mouse suppressors of cytokine signaling 1 (SOCS-1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS705857
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $550 +1 FREE 8GB USB
96-Strip-Wells  /  $795 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,890 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,465 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

suppressors of cytokine signaling 1 (SOCS-1), ELISA Kit

★Popular Item★
 Also Known As   

Mouse suppressors of cytokine signaling 1, SOCS-1 ELISA Kit

 Product Synonym Names    Mouse suppressors of cytokine signaling 1 (SOCS-1) ELISA Kit; CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3; JAK binding protein; STAT induced SH3 protein 1; Tec-interacting protein 3; cytokine-inducible SH2 protein 1; suppressors of cytokine signaling 1 (SOCS-1)
 Product Gene Name   

SOCS-1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS705857 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for O35716
 Species Reactivity    Mouse
Section Bar
 Specificity    This assay has high sensitivity and excellent specificity for detection of mouse SOCS-1. No significant cross-reactivity or interference between mouse SOCS-1 and analogues was observed.
Section Bar
 Samples    Serum, plasma, tissue homogenates
 Assay Type    Sandwich
 Detection Range    62.5 pg/ml -4000 pg/ml
 Sensitivity    15.6 pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
Section Bar
 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SOCS-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SOCS-1 purchase    MBS705857 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the suppressors of cytokine signaling 1 (SOCS-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5 pg/ml -4000 pg/ml in biological research samples containing SOCS-1, with an estimated sensitivity of 15.6 pg/ml. The ELISA analytical biochemical technique of the MBS705857 kit is based on SOCS-1 antibody-SOCS-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SOCS-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SOCS-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
Table BarTOPTable Bar
 

Product Description specifically for SOCS-1 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for SOCS-1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any SOCS-1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SOCS-1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SOCS-1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Section Bar
 Typical Testing Data/Standard Curve (for reference only) of SOCS-1 elisa kit    SOCS-1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
Table BarTOPTable Bar
Sample Manual Insert of MBS705857. Click to request current manual
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for SOCS-1. It may not necessarily be applicable to this product.
 NCBI GI #    409971432
 NCBI GeneID    12703
 NCBI Accession #    NP_001258532.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001271603.1 [Other Products]
Section Bar
 UniProt Primary Accession #    O35716 [Other Products]
 UniProt Secondary Accession #    O35960; Q3U3L0; A2RT46 [Other Products]
 UniProt Related Accession #    O35716 [Other Products]
 Molecular Weight    23,715 Da
Table BarTOPTable Bar
 NCBI Official Full Name    suppressor of cytokine signaling 1
 NCBI Official Synonym Full Names    suppressor of cytokine signaling 1
 NCBI Official Symbol    Socs1 [Similar Products]
 NCBI Official Synonym Symbols   
JAB; Cish1; Cish7; SSI-1; SOCS-1
[Similar Products]
 NCBI Protein Information    suppressor of cytokine signaling 1; JAK2-binding protein; STAT-induced STAT inhibitor 1; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7
 UniProt Protein Name    Suppressor of cytokine signaling 1
 UniProt Synonym Protein Names   
JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1
 UniProt Gene Name    Socs1 [Similar Products]
 UniProt Synonym Gene Names    Cish1; Ssi1; SOCS-1; JAB; SSI-1 [Similar Products]
 UniProt Entry Name    SOCS1_MOUSE
Section Bar
 UniProt Comments for SOCS-1    Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 SOCS1 appears to be a negative regulator in IGF1R signaling pathway 2 PublicationsManual assertion based on experiment in:Ref.14
Table BarTOPTable Bar
 Research Articles on SOCS-1    1. Data indicate that Leishmania exploits macrophage suppressors of cytokine signaling (SOCS) 1 and 3 proteins for inhibition of apoptosis, thus protecting its niche for survival and replication.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with SOCS-1 elisa kitPathways associated with SOCS-1 elisa kit
 Reference Product  PubMed Publications
 JAK2 elisa kit  >141 publications with SOCS-1 and JAK2
 JAK1 elisa kit  >65 publications with SOCS-1 and JAK1
 JAK3 elisa kit  >15 publications with SOCS-1 and JAK3
 GHR elisa kit  >9 publications with SOCS-1 and GHR
 CSF1R elisa kit  >9 publications with SOCS-1 and CSF1R
 IRS1 elisa kit  >8 publications with SOCS-1 and IRS1
 TIRAP elisa kit  >7 publications with SOCS-1 and TIRAP
 FLT3 elisa kit  >7 publications with SOCS-1 and FLT3
 EGFR elisa kit  >7 publications with SOCS-1 and EGFR
 KIT elisa kit  >6 publications with SOCS-1 and KIT
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 ECS Complex Pathway antibodies  ECS Complex Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 Growth Hormone Receptor Signaling Pathway antibodies  Growth Hormone Receptor Signaling Pathway Diagram
Diseases associated with SOCS-1 elisa kitOrgans/Tissues associated with SOCS-1 elisa kit
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >233 publications with SOCS-1 and Inflammation
 Necrosis Antibodies  >120 publications with SOCS-1 and Necrosis
 Liver Diseases Antibodies  >91 publications with SOCS-1 and Liver Diseases
 Disease Models, Animal Antibodies  >90 publications with SOCS-1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >60 publications with SOCS-1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >53 publications with SOCS-1 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >52 publications with SOCS-1 and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >50 publications with SOCS-1 and Nervous System Diseases
 Liver Neoplasms Antibodies  >48 publications with SOCS-1 and Liver Neoplasms
 Lung Diseases Antibodies  >36 publications with SOCS-1 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >63 publications with SOCS-1 and Bone
 Lung Antibodies  >41 publications with SOCS-1 and Lung
 Spleen Antibodies  >39 publications with SOCS-1 and Spleen
 Muscle Antibodies  >38 publications with SOCS-1 and Muscle
 Thymus Antibodies  >35 publications with SOCS-1 and Thymus
 Pancreas Antibodies  >34 publications with SOCS-1 and Pancreas
 Brain Antibodies  >32 publications with SOCS-1 and Brain
 Kidney Antibodies  >32 publications with SOCS-1 and Kidney
 Skin Antibodies  >30 publications with SOCS-1 and Skin
 Heart Antibodies  >28 publications with SOCS-1 and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions