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TJP1 elisa kit :: Mouse tight junction protein 1 (zona occludens 1) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9324491 TJP1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

tight junction protein 1 (zona occludens 1) (TJP1), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Tight junction protein ZO-1, TJP1 ELISA Kit

 Product Synonym Names    Mouse Tight junction protein ZO-1 (TJP1) ELISA kit; DKFZp686M05161; MGC133289; ZO-1; tight junction protein 1; tight junction protein ZO-1; zona occludens 1; zonula occludens 1 protein; tight junction protein 1 (zona occludens 1)
 Product Gene Name   

TJP1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS9324491 COA    COA PDF
 3D Structure    ModBase 3D Structure for P39447
 Species Reactivity    Mouse
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
 Assay Type    Sandwich
 Detection Range    0.25 ng/ml - 8 ng/ml.
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TJP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TJP1 purchase    MBS9324491 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the tight junction protein 1 (zona occludens 1) (TJP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25 ng/ml - 8 ng/ml in biological research samples containing TJP1, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9324491 kit is based on TJP1 antibody-TJP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TJP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TJP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TJP1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TJP1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9324491. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TJP1. It may not necessarily be applicable to this product.
 NCBI GI #    254675277
 NCBI GeneID    21872
 NCBI Accession #    NP_033412.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009386.2 [Other Products]
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 UniProt Primary Accession #    P39447 [Other Products]
 UniProt Secondary Accession #    E9QK00 [Other Products]
 UniProt Related Accession #    P39447 [Other Products]
 Molecular Weight    194,742 Da
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 NCBI Official Full Name    tight junction protein ZO-1 isoform 1
 NCBI Official Synonym Full Names    tight junction protein 1
 NCBI Official Symbol    Tjp1 [Similar Products]
 NCBI Official Synonym Symbols   
ZO1
[Similar Products]
 NCBI Protein Information    tight junction protein ZO-1; zona occludens protein 1; zonula occludens protein 1
 UniProt Protein Name    Tight junction protein ZO-1
 UniProt Synonym Protein Names   
Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1
 Protein Family    Tight junction protein
 UniProt Gene Name    Tjp1 [Similar Products]
 UniProt Synonym Gene Names    Zo1 [Similar Products]
 UniProt Entry Name    ZO1_MOUSE
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 UniProt Comments for TJP1    ZO1: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with tight junctions (TJ). May mediate dynamic changes in the composition of TJs. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting the protein kinase MRCKb to the leading edge of migrating cells. Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Forms homodimers and heterodimers with ZO-2 or ZO-3. Interacts with occludin, CALM, claudins, CGN, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with MRCKb and MYZAP. Interacts (via PDZ domain) with Cx43. ZO-2 and ZO-3 shuttle between the TJ and the nucleus, where they may regulate gene expression. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins can be up- or downregulated in cancer and are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Alternative splicing produces two isoforms. The long isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Cellular Component: apical junction complex; intercellular canaliculus; tight junction; cell surface; apicolateral plasma membrane; basolateral plasma membrane; intercellular junction; cell-cell adherens junction; adherens junction; membrane; apical part of cell; apical plasma membrane; cytoplasm; gap junction; plasma membrane; nucleus; cell junction

Molecular Function: calmodulin binding; protein C-terminus binding; protein domain specific binding; protein binding

Biological Process: sensory perception of sound; blastocyst formation
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 Research Articles on TJP1    1. Activation of RhoA/ROCK1 by high glucose in diabetic nephropathy disrupts the expression and translocation of occludin/ZO-1, which can be corrected by simvastatin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TJP1 elisa kitPathways associated with TJP1 elisa kit
 Reference Product  PubMed Publications
 Tjp2 elisa kit  >3 publications with TJP1 and Tjp2
 Ocln elisa kit  >3 publications with TJP1 and Ocln
 Cldn1 elisa kit  >3 publications with TJP1 and Cldn1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Regulation Of Gap Junction Activity Pathway antibodies  Regulation Of Gap Junction Activity Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
Diseases associated with TJP1 elisa kitOrgans/Tissues associated with TJP1 elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with TJP1 and Kidney Diseases
 Intestinal Diseases Antibodies  >2 publications with TJP1 and Intestinal Diseases
 Neural Tube Defects Antibodies  >1 publications with TJP1 and Neural Tube Defects
 Ovarian Neoplasms Antibodies  >1 publications with TJP1 and Ovarian Neoplasms
 Movement Disorders Antibodies  >1 publications with TJP1 and Movement Disorders
 Neovascularization, Pathologic Antibodies  >1 publications with TJP1 and Neovascularization, Pathologic
 Nervous System Diseases Antibodies  >1 publications with TJP1 and Nervous System Diseases
 Disease Models, Animal Antibodies  >1 publications with TJP1 and Disease Models, Animal
 Neoplasms Antibodies  >1 publications with TJP1 and Neoplasms
 Neurobehavioral Manifestations Antibodies  >1 publications with TJP1 and Neurobehavioral Manifestations
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >5 publications with TJP1 and Eye
 Testis Antibodies  >4 publications with TJP1 and Testis
 Muscle Antibodies  >4 publications with TJP1 and Muscle
 Kidney Antibodies  >3 publications with TJP1 and Kidney
 Intestine Antibodies  >2 publications with TJP1 and Intestine
 Brain Antibodies  >2 publications with TJP1 and Brain
 Skin Antibodies  >2 publications with TJP1 and Skin
 Embryonic Tissue Antibodies  >2 publications with TJP1 and Embryonic Tissue
 Uterus Antibodies  >1 publications with TJP1 and Uterus
 Stomach Antibodies  >1 publications with TJP1 and Stomach
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