NP_071300.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,027 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily V member 4
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily V, member 4
NCBI Official Synonym Symbols
Trp12; VRL-2; VROAC; OTRPC4; VR-OAC; 0610033B08Rik [Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily V member 4; trpv4 channel; osm-9-like TRP channel 4; vanilloid receptor-like channel 2; vanilloid receptor-like protein 2; transient receptor potential protein 12; osmosensitive transient receptor potential channel 4; vanilloid receptor-related osmotically-activated channel
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 4
UniProt Synonym Protein Names
Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12; Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; Vanilloid receptor-related osmotically-activated channel; VR-OAC
UniProt Synonym Gene Names
UniProt Entry Name
TRPV4_MOUSE
UniProt Comments for TRPV4
TRPV4: a non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV4 sub-subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation
Cellular Component: cortical actin cytoskeleton; focal adhesion; cell surface; cell; integral to membrane; cytosol; cilium; growth cone; adherens junction; membrane; cytoplasmic microtubule; lamellipodium; plasma membrane; cytoplasmic vesicle; cell junction; filopodium
Molecular Function: microtubule binding; calcium channel activity; ion channel activity; nucleotide binding; beta-tubulin binding; actin binding; protein kinase binding; actin filament binding; calmodulin binding; protein binding; protein kinase C binding; osmosensor activity; cation channel activity; SH2 domain binding; alpha-tubulin binding; ATP binding
Biological Process: intercellular junction assembly; hypotonic response; actin filament organization; response to osmotic stress; regulation of response to osmotic stress; cellular calcium ion homeostasis; osmosensory signaling pathway; vasopressin secretion; positive regulation of microtubule depolymerization; elevation of cytosolic calcium ion concentration; hyperosmotic salinity response; transport; calcium ion transport; actin cytoskeleton reorganization; ion transport; cortical microtubule organization and biogenesis; transmembrane transport; microtubule polymerization
Research Articles on TRPV4
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Diseases associated with TRPV4 elisa kit
Organs/Tissues associated with TRPV4 elisa kit
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