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TMPRSS6 elisa kit :: Mouse transmembrane protease, serine 6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS931047
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

transmembrane protease, serine 6 (TMPRSS6), ELISA Kit

 Also Known As   

Mouse Transmembrane protease serine 6, TMPRSS6 ELISA Kit

 Product Synonym Names    Mouse Transmembrane protease serine 6 (TMPRSS6) ELISA kit; RP5-1170K4.5; IRIDA; membrane-bound mosaic serine proteinase matriptase-2; type II transmembrane serine protease 6; transmembrane protease; serine 6
 Product Gene Name   

TMPRSS6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS931047 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for Q9DBI0
 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of mouse TMPRSS6. No significant cross-reactivity or interference between mouse TMPRSS6 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    0.156 ng/ml -10 ng/ml.
 Sensitivity    The minimum detectable dose of mouse TMPRSS6 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of TMPRSS6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TMPRSS6 purchase    MBS931047 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the transmembrane protease, serine 6 (TMPRSS6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156 ng/ml -10 ng/ml in biological research samples containing TMPRSS6, with an estimated sensitivity of The minimum detectable dose of mouse TMPRSS6 is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS931047 kit is based on TMPRSS6 antibody-TMPRSS6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TMPRSS6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TMPRSS6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for TMPRSS6 elisa kit

  
Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for TMPRSS6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any TMPRSS6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TMPRSS6 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TMPRSS6 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of TMPRSS6 elisa kit    TMPRSS6 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS931047
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NCBI/Uniprot data below describe general gene information for TMPRSS6. It may not necessarily be applicable to this product.
 NCBI GI #    125656152
 NCBI GeneID    71753
 NCBI Accession #    NP_082178.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_027902.2 [Other Products]
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 UniProt Primary Accession #    Q9DBI0 [Other Products]
 UniProt Secondary Accession #    Q3KN88; Q6PF94; A8W478; A8W479 [Other Products]
 UniProt Related Accession #    Q9DBI0 [Other Products]
 Molecular Weight    90,978 Da
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 NCBI Official Full Name    transmembrane protease serine 6
 NCBI Official Synonym Full Names    transmembrane serine protease 6
 NCBI Official Symbol    Tmprss6 [Similar Products]
 NCBI Official Synonym Symbols   
1300008A22Rik
[Similar Products]
 NCBI Protein Information    transmembrane protease serine 6; matriptase 2; matriptase-2; transmembrane protease, serine 6; type II transmembrane serine protease 6
 UniProt Protein Name    Transmembrane protease serine 6
 UniProt Synonym Protein Names   
Matriptase-2
 Protein Family    Transmembrane protease serine
 UniProt Gene Name    Tmprss6 [Similar Products]
 UniProt Entry Name    TMPS6_MOUSE
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 UniProt Comments for TMPRSS6    TMPRSS6: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Plays a role in the regulation of iron homeostasis, a process involving HAMP. Required to sense iron deficiency and suppress activation of the HAMP promoter. Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA); also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron. Mutations leading to abrogation of TMPRSS6 activity are associated with IRIDA due to elevated levels of hepcidin, a negative regulator of plasma iron pool (PubMed:20232450). Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.4.21.-; Protease

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity

Biological Process: fibrinolysis; iron ion homeostasis; proteolysis; negative regulation of BMP signaling pathway
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 Research Articles on TMPRSS6    1. Loss of matriptase-2 increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin protein content.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with TMPRSS6 elisa kitOrgans/Tissues associated with TMPRSS6 elisa kit
 Disease Name  Pubmed Publications
 Anemia, Iron-Deficiency Antibodies  >65 publications with TMPRSS6 and Anemia, Iron-Deficiency
 Iron-Refractory Iron Deficiency Anemia Antibodies  >26 publications with TMPRSS6 and Iron-Refractory Iron Deficiency Anemia
 Inflammation Antibodies  >13 publications with TMPRSS6 and Inflammation
 Liver Diseases Antibodies  >7 publications with TMPRSS6 and Liver Diseases
 Anemia, Hemolytic Antibodies  >7 publications with TMPRSS6 and Anemia, Hemolytic
 Carcinoma, Hepatocellular Antibodies  >4 publications with TMPRSS6 and Carcinoma, Hepatocellular
 Carcinoma Antibodies  >4 publications with TMPRSS6 and Carcinoma
 Kidney Diseases Antibodies  >2 publications with TMPRSS6 and Kidney Diseases
 Fatty Liver Antibodies  >2 publications with TMPRSS6 and Fatty Liver
 Liver Neoplasms Antibodies  >2 publications with TMPRSS6 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >25 publications with TMPRSS6 and Liver
 Spleen Antibodies  >1 publications with TMPRSS6 and Spleen
 Muscle Antibodies  >1 publications with TMPRSS6 and Muscle
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