NP_001129557.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
117,809 Da
NCBI Official Full Name
ubiquitin-like modifier-activating enzyme 1 isoform 2
NCBI Official Synonym Full Names
ubiquitin-like modifier activating enzyme 1
NCBI Protein Information
ubiquitin-like modifier-activating enzyme 1; ubiquitin-activating enzyme E1, Chr X
UniProt Protein Name
Ubiquitin-like modifier-activating enzyme 1
UniProt Synonym Protein Names
Ubiquitin-activating enzyme E1; Ubiquitin-activating enzyme E1 X; Ubiquitin-like modifier-activating enzyme 1 X
UniProt Synonym Gene Names
UniProt Entry Name
UBA1_MOUSE
NCBI Summary for UBA1
This gene encodes a member of the ubiquitin-activating E1 family. The encoded protein initiates the ubiquitin activation and transfer cascade, catalyzing the first step in ubiquitin conjugation to mark cellular proteins for proteasome degradation. Ubiquitin activating enzymes use ATP to form a thioester between a conserved catalytic cysteine of the enzyme and the C-terminal carboxylate of ubiquitin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Comments for UBA1
UBE1: an enzyme of the ubiquitin-activating E1 family. Adenylates ubiquitin at its carboxy-terminal glycine residue and thereafter links this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester. There are two active sites within the E1 molecule, allowing it to accomodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair.
Protein type: Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.19
Cellular Component: heterochromatin; desmosome; mitochondrion; lysosomal membrane; cytoplasm; endosome membrane; rough endoplasmic reticulum membrane; cytosol; nucleus
Molecular Function: protein binding; small protein activating enzyme activity; ubiquitin-protein ligase activity; nucleotide binding; ubiquitin activating enzyme activity; ATP binding; ligase activity
Biological Process: modification-dependent protein catabolic process; protein modification process; protein ubiquitination; response to DNA damage stimulus
Research Articles on UBA1
Precautions
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Pathways associated with UBA1 elisa kit
Diseases associated with UBA1 elisa kit
Organs/Tissues associated with UBA1 elisa kit
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