NP_001193780.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
80,479 Da
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase 44 isoform 1
NCBI Official Synonym Full Names
ubiquitin specific peptidase 44
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase 44; ubiquitin thioesterase 44; deubiquitinating enzyme 44; inactive ubiquitin thioesterase 44; inactive deubiquitinating enzyme 44; ubiquitin-specific-processing protease 44; ubiquitin specific peptidase 49 pseudogene; inactive ubiquitin carboxyl-terminal hydrolase 44; inactive ubiquitin-specific-processing protease 44
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase 44
UniProt Synonym Protein Names
Deubiquitinating enzyme 44; Ubiquitin thioesterase 44; Ubiquitin-specific-processing protease 44
UniProt Entry Name
UBP44_MOUSE
UniProt Comments for USP44
USP44: Deubiquitinase that plays a key role in the spindle checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20- APC/C ternary complex (also named mitotic checkpoint), thereby preventing premature activation of the APC/C. Belongs to the peptidase C19 family. USP44 subfamily.
Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Protease
Cellular Component: microtubule cytoskeleton; nucleolus; nucleus
Molecular Function: peptidase activity; hydrolase activity; zinc ion binding; metal ion binding; ubiquitin-specific protease activity; cysteine-type peptidase activity
Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; mitosis; protein deubiquitination; cell division; cell cycle; proteolysis
Research Articles on USP44
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Diseases associated with USP44 elisa kit
Organs/Tissues associated with USP44 elisa kit
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