NP_001154900.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,981 Da
NCBI Official Full Name
protein unc-93 homolog B1 isoform b
NCBI Official Synonym Full Names
unc-93 homolog B1 (C. elegans)
NCBI Protein Information
protein unc-93 homolog B1
UniProt Protein Name
Protein unc-93 homolog B1
UniProt Synonym Gene Names
UniProt Entry Name
UN93B_MOUSE
UniProt Comments for UNC93B1
UNC93B1: Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal. Defects in UNC93B1 are associated with herpes simplex encephalitis type 1 (HSE1). HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Mutations in UNC93B1 resulting in autosomal recessive UNC93B1 deficieny predispose otherwise healthy individuals to isolated herpes simplex encephalitis due to impaired IFNs production. UNC93B1 deficieny, however, does not compromise immunity to most pathogens, unlike most known primary immunodeficiencies. Belongs to the unc-93 family.
Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-pass
Cellular Component: membrane; lysosome; cell; endoplasmic reticulum; integral to membrane; intracellular; cytoplasmic vesicle; endosome
Molecular Function: protein binding
Biological Process: intracellular protein transport; immune system process; toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; innate immune response; toll-like receptor 3 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor 7 signaling pathway; defense response to virus
Research Articles on UNC93B1
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Products associated with UNC93B1 elisa kit
Pathways associated with UNC93B1 elisa kit
Diseases associated with UNC93B1 elisa kit
Organs/Tissues associated with UNC93B1 elisa kit
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