NP_808213.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,064 Da
NCBI Official Full Name
vang-like protein 1 isoform 1
NCBI Official Synonym Full Names
vang-like 1 (van gogh, Drosophila)
NCBI Protein Information
vang-like protein 1; strabismus; loop-tail protein 2; vang, van gogh-like 1; van Gogh-like protein 1; KAI1 COOH-terminal interacting tetraspanin
UniProt Protein Name
Vang-like protein 1
UniProt Synonym Protein Names
Loop-tail protein 2; Van Gogh-like protein 1
UniProt Synonym Gene Names
UniProt Entry Name
VANG1_MOUSE
UniProt Comments for VANGL1
VANGL1: Defects in VANGL1 are a cause of neural tube defects (NTD). NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis). Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM). SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. Belongs to the Vang family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: membrane; plasma membrane; integral to membrane; lateral plasma membrane
Molecular Function: protein binding
Biological Process: multicellular organismal development
Research Articles on VANGL1
Precautions
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Pathways associated with VANGL1 elisa kit
Diseases associated with VANGL1 elisa kit
Organs/Tissues associated with VANGL1 elisa kit
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