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LCN2 elisa kit :: NGAL (Lipocalin-2) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS564146 LCN2 elisa kit
Unit / Price
1x96 Wells  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NGAL (Lipocalin-2) (LCN2), ELISA Kit

★Popular Item★
 Also Known As   

Dog NGAL ELISA Kit

 Product Synonym Names    Dog NGAL (Lipocalin-2)
 Product Gene Name   

LCN2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 9; NC_000009.11 (130911732..130915734). Location: 9q34
 OMIM    600181
 3D Structure    ModBase 3D Structure for P80188
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 Host    Dog
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 Samples    Immunoperoxidase Assay for Determination of NGAL in Dog Samples
 Assay Type    Sandwich
 Intended Uses    The NGAL test kit is a highly sensitive two-site enzyme linked immunoassay (ELISA) for measuring NGAL in biological samples of dogs.
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 Preparation and Storage    Store at 4 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LCN2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LCN2 purchase    MBS564146 is a ready-to-use microwell, strip-or-full plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dog NGAL (Lipocalin-2) (LCN2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LCN2. The ELISA analytical biochemical technique of the MBS564146 kit is based on LCN2 antibody-LCN2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LCN2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LCN2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Immunoperoxidase Assay for Determination of NGAL in Dog Samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for LCN2 elisa kit

   Principle of the Assay: The principle of the double antibody sandwich ELISA is represented in Figure 1. In this assay the NGAL present in samples reacts with the anti-NGAL antibodies which have been adsorbed to the surface of polystyrene microtitre wells. After the removal of unbound proteins by washing, the Detection Antibody, biotin conjugated anti-NGAL, is added and complexes are formed. Following a wash step, the horseradish peroxidase (HRP) conjugated Streptavidin is added and complexes are formed. After another washing step, the complexes are assayed by the addition of a chromogenic substrate, 3,3',5,5'-tetramethylbenzidine (TMB). The quantity of bound enzyme varies directly with the concentration of NGAL in the sample tested; thus, the absorbance, at 450 nm, is a measure of the concentration of NGAL in the test sample. The quantity of NGAL in the test sample can be interpolated from the standard curve constructed from the standards, and corrected for sample dilution.
 Product Categories/Family for LCN2 elisa kit    ELISA Kit
Sample Manual Insert of MBS564146. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LCN2. It may not necessarily be applicable to this product.
 NCBI GI #    38455402
 NCBI GeneID    3934
 NCBI Accession #    NP_005555.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005564.3 [Other Products]
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 UniProt Primary Accession #    P80188 [Other Products]
 UniProt Secondary Accession #    P30150; Q5SYV9; Q5SYW0; Q6FGL5; Q92683; A6NII8; B4DWV4; B7ZAA2 [Other Products]
 UniProt Related Accession #    P80188 [Other Products]
 Molecular Weight    22,588 Da [Similar Products]
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 NCBI Official Full Name    neutrophil gelatinase-associated lipocalin
 NCBI Official Synonym Full Names    lipocalin 2
 NCBI Official Symbol    LCN2 [Similar Products]
 NCBI Official Synonym Symbols   
24p3; MSFI; NGAL
[Similar Products]
 NCBI Protein Information    neutrophil gelatinase-associated lipocalin; p25; lipocalin-2; siderocalin; oncogene 24p3; OTTHUMP00000022238; OTTHUMP00000022239; OTTHUMP00000022240; migration-stimulating factor inhibitor; 25 kDa alpha-2-microglobulin-related subunit of MMP-9
 UniProt Protein Name    Neutrophil gelatinase-associated lipocalin
 UniProt Synonym Protein Names   
25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; p25
 Protein Family    Neutrophil gelatinase-associated lipocalin
 UniProt Gene Name    LCN2 [Similar Products]
 UniProt Synonym Gene Names    HNL; NGAL [Similar Products]
 UniProt Entry Name    NGAL_HUMAN
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 UniProt Comments for LCN2    LCN2: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. Belongs to the calycin superfamily. Lipocalin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: extracellular space; extracellular region; cytosol

Molecular Function: protein homodimerization activity; protease binding; transporter activity; iron ion binding

Biological Process: response to drug; cellular response to nutrient levels; cellular iron ion homeostasis; response to virus; positive regulation of cell projection organization and biogenesis; siderophore transport; innate immune response; ion transport; response to herbicide; transmembrane transport
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 Research Articles on LCN2    1. LCN2 expression shows clear correlation to liver damage and resulting inflammatory responses, rather than to the degree of liver fibrosis, which in fact may imply a distinct diagnostic value as an early biomarker of liver inflammation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LCN2 elisa kitDiseases associated with LCN2 elisa kit
 Reference Product  PubMed Publications
 MMP9 elisa kit  >6 publications with LCN2 and MMP9
 MMP2 elisa kit  >2 publications with LCN2 and MMP2
 HGF elisa kit  >2 publications with LCN2 and HGF
 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >225 publications with LCN2 and Female Urogenital Diseases
 Kidney Diseases Antibodies  >212 publications with LCN2 and Kidney Diseases
 Acute Kidney Injury Antibodies  >188 publications with LCN2 and Acute Kidney Injury
 Renal Insufficiency Antibodies  >133 publications with LCN2 and Renal Insufficiency
 Inflammation Antibodies  >118 publications with LCN2 and Inflammation
 Neoplasms Antibodies  >99 publications with LCN2 and Neoplasms
 Cardiovascular Diseases Antibodies  >62 publications with LCN2 and Cardiovascular Diseases
 Carcinoma Antibodies  >40 publications with LCN2 and Carcinoma
 Lung Diseases Antibodies  >29 publications with LCN2 and Lung Diseases
 Liver Diseases Antibodies  >25 publications with LCN2 and Liver Diseases
Organs/Tissues associated with LCN2 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >324 publications with LCN2 and Blood
 Kidney Antibodies  >245 publications with LCN2 and Kidney
 Liver Antibodies  >53 publications with LCN2 and Liver
 Lung Antibodies  >43 publications with LCN2 and Lung
 Brain Antibodies  >29 publications with LCN2 and Brain
 Bone Antibodies  >21 publications with LCN2 and Bone
 Bone Marrow Antibodies  >18 publications with LCN2 and Bone Marrow
 Connective Tissue Antibodies  >17 publications with LCN2 and Connective Tissue
 Uterus Antibodies  >14 publications with LCN2 and Uterus
 Embryonic Tissue Antibodies  >12 publications with LCN2 and Embryonic Tissue
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