AAA62379.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,051 Da
NCBI Official Full Name
1,25-dihydroxyvitamin D3 24-hydroxylase
NCBI Official Synonym Full Names
cytochrome P450 family 24 subfamily A member 1
NCBI Protein Information
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
UniProt Protein Name
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
UniProt Synonym Protein Names
Cytochrome P450 24A1; Cytochrome P450-CC24
UniProt Synonym Gene Names
UniProt Entry Name
CP24A_HUMAN
NCBI Summary for 1,25 DHVD3
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for 1,25 DHVD3
CYP24A1: Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product. Defects in CYP24A1 are the cause of hypercalcemia infantile (HCAI). HCAI is a disorder characterized by abnormally high level of calcium in the blood, failure to thrive, vomiting, dehydration, and nephrocalcinosis. Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; EC 1.14.13.126; Oxidoreductase
Chromosomal Location of Human Ortholog: 20q13
Cellular Component: mitochondrial inner membrane; mitochondrion; nucleoplasm; nucleus; plasma membrane
Molecular Function: 1-alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) 24-hydroxylase activity; 25-hydroxycholecalciferol-24-hydroxylase activity; heme binding; iron ion binding; oxidoreductase activity
Biological Process: fat-soluble vitamin metabolic process; osteoblast differentiation; response to vitamin D; vitamin D catabolic process; vitamin D metabolic process; vitamin metabolic process; xenobiotic metabolic process
Disease: Hypercalcemia, Infantile
Research Articles on 1,25 DHVD3
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Products associated with 1,25 DHVD3 elisa kit
Pathways associated with 1,25 DHVD3 elisa kit
Diseases associated with 1,25 DHVD3 elisa kit
Disease Name |
Pubmed Publications |
Kidney Diseases Antibodies |
>108 publications with 1,25 DHVD3 and Kidney Diseases |
Hypercalcemia Antibodies |
>81 publications with 1,25 DHVD3 and Hypercalcemia |
Prostatic Neoplasms Antibodies |
>64 publications with 1,25 DHVD3 and Prostatic Neoplasms |
Breast Neoplasms Antibodies |
>56 publications with 1,25 DHVD3 and Breast Neoplasms |
Renal Insufficiency Antibodies |
>33 publications with 1,25 DHVD3 and Renal Insufficiency |
Disease Models, Animal Antibodies |
>32 publications with 1,25 DHVD3 and Disease Models, Animal |
Inflammation Antibodies |
>31 publications with 1,25 DHVD3 and Inflammation |
Nervous System Diseases Antibodies |
>23 publications with 1,25 DHVD3 and Nervous System Diseases |
Cardiovascular Diseases Antibodies |
>19 publications with 1,25 DHVD3 and Cardiovascular Diseases |
Lung Neoplasms Antibodies |
>17 publications with 1,25 DHVD3 and Lung Neoplasms |
Organs/Tissues associated with 1,25 DHVD3 elisa kit
Organ/Tissue Name |
Pubmed Publications |
Kidney Antibodies |
>371 publications with 1,25 DHVD3 and Kidney |
Blood Antibodies |
>287 publications with 1,25 DHVD3 and Blood |
Intestine Antibodies |
>124 publications with 1,25 DHVD3 and Intestine |
Skin Antibodies |
>94 publications with 1,25 DHVD3 and Skin |
Prostate Antibodies |
>86 publications with 1,25 DHVD3 and Prostate |
Liver Antibodies |
>84 publications with 1,25 DHVD3 and Liver |
Embryonic Tissue Antibodies |
>25 publications with 1,25 DHVD3 and Embryonic Tissue |
Brain Antibodies |
>24 publications with 1,25 DHVD3 and Brain |
Mammary Gland Antibodies |
>7 publications with 1,25 DHVD3 and Mammary Gland |
Cervix Antibodies |
>4 publications with 1,25 DHVD3 and Cervix |
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