NP_999468.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,246 Da
NCBI Official Full Name
2'-5'-oligoadenylate synthase 1
NCBI Protein Information
2'-5'-oligoadenylate synthase 1
UniProt Protein Name
2'-5'-oligoadenylate synthase 1
UniProt Synonym Protein Names
p42 OAS
UniProt Synonym Gene Names
UniProt Entry Name
OAS1_PIG
UniProt Comments for OAS1
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
Research Articles on OAS1
Precautions
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Disclaimer
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Pathways associated with OAS1 elisa kit
Diseases associated with OAS1 elisa kit
Disease Name |
Pubmed Publications |
Virus Diseases Antibodies |
>76 publications with OAS1 and Virus Diseases |
Liver Diseases Antibodies |
>31 publications with OAS1 and Liver Diseases |
Inflammation Antibodies |
>19 publications with OAS1 and Inflammation |
Diabetes Mellitus, Type 1 Antibodies |
>8 publications with OAS1 and Diabetes Mellitus, Type 1 |
Necrosis Antibodies |
>7 publications with OAS1 and Necrosis |
Influenza, Human Antibodies |
>7 publications with OAS1 and Influenza, Human |
Carcinoma, Hepatocellular Antibodies |
>4 publications with OAS1 and Carcinoma, Hepatocellular |
Neoplasms, Experimental Antibodies |
>3 publications with OAS1 and Neoplasms, Experimental |
Arthritis, Rheumatoid Antibodies |
>3 publications with OAS1 and Arthritis, Rheumatoid |
Breast Neoplasms Antibodies |
>2 publications with OAS1 and Breast Neoplasms |
Organs/Tissues associated with OAS1 elisa kit
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