NP_999382.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,676 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2A
NCBI Official Synonym Symbols
NCBI Protein Information
5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; 5-HT2A receptor; serotonin receptor 2A
UniProt Protein Name
5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names
Serotonin receptor 2A
UniProt Synonym Gene Names
UniProt Entry Name
5HT2A_PIG
UniProt Comments for HTR2A
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction
Research Articles on HTR2A
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Pathways associated with HTR2A elisa kit
Diseases associated with HTR2A elisa kit
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