Q29005.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
6,725 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2B
NCBI Official Synonym Symbols
NCBI Protein Information
5-hydroxytryptamine receptor 2B; 5-HT-2B; serotonin 2B receptor; serotonin receptor 2B
UniProt Protein Name
5-hydroxytryptamine receptor 2B
UniProt Synonym Protein Names
Serotonin receptor 2B
UniProt Synonym Gene Names
UniProt Entry Name
5HT2B_PIG
UniProt Comments for HTR2B
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine
Research Articles on HTR2B
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Pathways associated with HTR2B elisa kit
Organs/Tissues associated with HTR2B elisa kit
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