NP_999053.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
39,692 Da
NCBI Official Full Name
membrane cofactor protein
NCBI Official Synonym Symbols
NCBI Protein Information
membrane cofactor protein; CD46 complement regulatory protein
UniProt Protein Name
Membrane cofactor protein
UniProt Synonym Protein Names
CD_antigen: CD46
UniProt Synonym Gene Names
UniProt Entry Name
MCP_PIG
UniProt Comments for CD46
Function: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. May act as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity.2 PublicationsManual assertion based on experiment in:Ref.1
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Pathways associated with CD46 elisa kit
Diseases associated with CD46 elisa kit
Organs/Tissues associated with CD46 elisa kit
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