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ADAM17 elisa kit :: Pig Disintegrin and metalloproteinase domain-containing protein 17 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS281226 ADAM17 elisa kit
Unit / Price
48-Strip-Wells  /  $465 +1 FREE 8GB USB
96-Strip-Wells  /  $790 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,500 +4 FREE 8GB USB
10x96-Strip-Wells  /  $6,655 +8 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), ELISA Kit

 Also Known As   

Pig Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) ELISA Kit

 Product Gene Name   

ADAM17 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O77636
 Species Reactivity    Pig
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Pig ADAM17. No significant cross-reactivity or interference between Pig ADAM17 and analogues was observed.
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 Samples    Serum, Plasma, Other biological fluids
 Assay Type    Sandwich
 Sample Volume    1-200 uL
 Precision    Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
 Detection Wavelength    450 nm
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 Preparation and Storage    Store at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ADAM17 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ADAM17 purchase    MBS281226 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAM17. The ELISA analytical biochemical technique of the MBS281226 kit is based on ADAM17 antibody-ADAM17 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAM17 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAM17. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Other biological fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ADAM17 elisa kit

   Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate ADAM17 in samples. An antibody specific for ADAM17 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyADAM17 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ADAM17 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ADAM17 bound in the initial step. The color development is stopped and the intensity of the color is measured.
NCBI/Uniprot data below describe general gene information for ADAM17. It may not necessarily be applicable to this product.
 NCBI GI #    14423629
 NCBI GeneID    397343
 NCBI Accession #    O77636.1 [Other Products]
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 UniProt Primary Accession #    O77636 [Other Products]
 UniProt Related Accession #    O77636 [Other Products]
 Molecular Weight    12,201 Da
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 NCBI Official Full Name    Disintegrin and metalloproteinase domain-containing protein 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
TACE
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
TNF-alpha convertase; TNF-alpha-converting enzyme; CD_antigen: CD156b
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    TACE; ADAM 17 [Similar Products]
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 UniProt Comments for ADAM17    Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2 ().
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 Research Articles on ADAM17    1. these findings provide the direct evidence that ADAM17 cleaves porcine TNFalpha, which represents a new view for identifying potential therapeutic targets in anti-porcine reproductive and respiratory syndrome virus therapy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAM17 elisa kitPathways associated with ADAM17 elisa kit
 Reference Product  PubMed Publications
 EGFR elisa kit  >159 publications with ADAM17 and EGFR
 TIMP-3 elisa kit  >41 publications with ADAM17 and TIMP-3
 DLL1 elisa kit  >2 publications with ADAM17 and DLL1
 NOTCH2 elisa kit  >2 publications with ADAM17 and NOTCH2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Death Receptor Signalling Pathway antibodies  Death Receptor Signalling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Regulated Proteolysis Of P75NTR Pathway antibodies  Regulated Proteolysis Of P75NTR Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
Organs/Tissues associated with ADAM17 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >180 publications with ADAM17 and Blood
 Brain Antibodies  >87 publications with ADAM17 and Brain
 Lung Antibodies  >50 publications with ADAM17 and Lung
 Muscle Antibodies  >47 publications with ADAM17 and Muscle
 Embryonic Tissue Antibodies  >34 publications with ADAM17 and Embryonic Tissue
 Skin Antibodies  >31 publications with ADAM17 and Skin
 Ovary Antibodies  >20 publications with ADAM17 and Ovary
 Intestine Antibodies  >17 publications with ADAM17 and Intestine
 Lymph Node Antibodies  >13 publications with ADAM17 and Lymph Node
 Prostate Antibodies  >13 publications with ADAM17 and Prostate
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