NP_999327.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
44,882 Da
NCBI Official Full Name
caspase-1
NCBI Protein Information
caspase-1; ICE; p45; CASP-1; IL-1BC; IL-1 beta-converting enzyme; interleukin-1 beta convertase; interleukin-1 beta converting enzyme; interleukin-1 beta-converting enzyme; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
UniProt Protein Name
Caspase-1
UniProt Synonym Protein Names
Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45Cleaved into the following 2 chains:Caspase-1 subunit p20; Caspase-1 subunit p10
UniProt Synonym Gene Names
UniProt Entry Name
CASP1_PIG
UniProt Comments for CASP1
Function: Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis
Catalytic activity: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|-.
Research Articles on CASP1
Precautions
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Disclaimer
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Pathways associated with CASP1 elisa kit
Diseases associated with CASP1 elisa kit
Organs/Tissues associated with CASP1 elisa kit
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