NP_999378.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
6,080 Da
NCBI Official Full Name
cardiac phospholamban
NCBI Protein Information
cardiac phospholamban; PLB
UniProt Protein Name
Cardiac phospholamban
UniProt Synonym Gene Names
UniProt Entry Name
PPLA_PIG
UniProt Comments for PLN
PLB: a heart protein postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum. A major substrate for the cAMP-dependent protein kinase. An inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. A key regulator of cardiac diastolic function. Mutations are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.
Protein type: Membrane protein, integral; Inhibitor
Cellular Component: sarcoplasmic reticulum membrane; mitochondrial membrane
Molecular Function: ATPase inhibitor activity; calcium channel regulator activity
Biological Process: cardiac muscle development; cellular calcium ion homeostasis; negative regulation of heart rate; calcium ion transport; regulation of calcium ion transport
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Pathways associated with PLN elisa kit
Diseases associated with PLN elisa kit
Organs/Tissues associated with PLN elisa kit
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