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FLT4 elisa kit :: Pig soluble vascular endothelial growth factor receptor-2, VEGFR-2/sFLK-1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2602993 FLT4 elisa kit
Unit / Price
48-Strip-Wells  /  $300 +1 FREE 8GB USB
96-Strip-Wells  /  $475 +1 FREE 8GB USB
5x96-Strip-Wells  /  $1,825 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,425 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

soluble vascular endothelial growth factor receptor-2, VEGFR-2/sFLK-1 (FLT4), ELISA Kit

 Also Known As   

Pig soluble vascular endothelial growth factor receptor-2, VEGFR-2/sFLK-1 ELISA Kit

 Product Gene Name   

FLT4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    602089
 3D Structure    ModBase 3D Structure for P35916
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 Species Reactivity    Pig
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of FLT4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for FLT4 purchase    MBS2602993 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the soluble vascular endothelial growth factor receptor-2, VEGFR-2/sFLK-1 (FLT4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FLT4. The ELISA analytical biochemical technique of the MBS2602993 kit is based on FLT4 antibody-FLT4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FLT4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FLT4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for FLT4. It may not necessarily be applicable to this product.
 NCBI GI #    104294888
 NCBI GeneID    2324
 NCBI Accession #    NP_891555.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_182925.4 [Other Products]
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 UniProt Primary Accession #    P35916 [Other Products]
 UniProt Secondary Accession #    Q16067; Q86W07; Q86W08; A8K6L4; B5A926 [Other Products]
 UniProt Related Accession #    P35916; AAB23636 [Other Products]
 Molecular Weight    93,174 Da [Similar Products]
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 NCBI Official Full Name    vascular endothelial growth factor receptor 3 isoform 1
 NCBI Official Synonym Full Names    fms-related tyrosine kinase 4
 NCBI Official Symbol    FLT4 [Similar Products]
 NCBI Official Synonym Symbols   
PCL; FLT41; LMPH1A; VEGFR3
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor receptor 3; FLT-4; VEGFR-3; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; fms-like tyrosine kinase 4; tyrosine-protein kinase receptor FLT4
 UniProt Protein Name    Vascular endothelial growth factor receptor 3
 UniProt Synonym Protein Names   
Fms-like tyrosine kinase 4; FLT-4; Tyrosine-protein kinase receptor FLT4
 Protein Family    Vascular endothelial growth factor receptor
 UniProt Gene Name    FLT4 [Similar Products]
 UniProt Synonym Gene Names    VEGFR3; VEGFR-3; FLT-4 [Similar Products]
 UniProt Entry Name    VGFR3_HUMAN
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 NCBI Summary for FLT4    This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
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 UniProt Comments for FLT4    VEGFR3: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr- 185', and of AKT1 at 'Ser-473'. Interacts with VEGFC and VEGFD. Monomer in the absence of bound VEGFC or VEGFD. Homodimer in the presence of bound VEGFC or VEGFD. Can also form a heterodimer with KDR. Interacts with PTPN14; the interaction is enhanced by stimulation with VEGFC. Interacts with CRK, GRB2, PTK2/FAK1, SHC1, PIK3R1 and PTPN11/SHP- 2. Identified in a complex with SRC and ITGB1. Detected in endothelial cells. Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney. Present in an inactive conformation in the absence of bound ligand. Binding of VEGFC or VEGFD leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by MAZ51. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; VEGFR family

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: integral to plasma membrane; cytoplasm; extracellular region; plasma membrane; nucleus; receptor complex

Molecular Function: vascular endothelial growth factor receptor activity; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of JNK cascade; positive regulation of MAPKKK cascade; vasculature development; lymphangiogenesis; positive regulation of cell proliferation; blood vessel morphogenesis; positive regulation of endothelial cell proliferation; sprouting angiogenesis; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; lymph vessel development; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis

Disease: Hemangioma, Capillary Infantile; Lymphedema, Hereditary, Ia
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 Research Articles on FLT4    1. The CXCL12-CXCR4 axis may influence the expression of VEGFR3 in urothelial bladder carcinoma and promote tumor recurrence.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FLT4 elisa kitPathways associated with FLT4 elisa kit
 Reference Product  PubMed Publications
 KDR elisa kit  >45 publications with FLT4 and KDR
 VEGFC elisa kit  >36 publications with FLT4 and VEGFC
 VEGFA elisa kit  >17 publications with FLT4 and VEGFA
 FIGF elisa kit  >6 publications with FLT4 and FIGF
 GRB2 elisa kit  >4 publications with FLT4 and GRB2
 PGF elisa kit  >3 publications with FLT4 and PGF
 VEGFB elisa kit  >3 publications with FLT4 and VEGFB
 SHC1 elisa kit  >1 publications with FLT4 and SHC1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
Diseases associated with FLT4 elisa kitOrgans/Tissues associated with FLT4 elisa kit
 Disease Name  Pubmed Publications
 Lymphedema Antibodies  >29 publications with FLT4 and Lymphedema
 Lymphatic Diseases Antibodies  >28 publications with FLT4 and Lymphatic Diseases
 Carcinoma Antibodies  >18 publications with FLT4 and Carcinoma
 Edema Antibodies  >10 publications with FLT4 and Edema
 Adenocarcinoma Antibodies  >7 publications with FLT4 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >7 publications with FLT4 and Neoplasms, Experimental
 Leukemia, Myeloid, Acute Antibodies  >4 publications with FLT4 and Leukemia, Myeloid, Acute
 Inflammation Antibodies  >4 publications with FLT4 and Inflammation
 Kidney Diseases Antibodies  >3 publications with FLT4 and Kidney Diseases
 Breast Neoplasms Antibodies  >3 publications with FLT4 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >94 publications with FLT4 and Vascular
 Embryonic Tissue Antibodies  >15 publications with FLT4 and Embryonic Tissue
 Lung Antibodies  >14 publications with FLT4 and Lung
 Placenta Antibodies  >11 publications with FLT4 and Placenta
 Muscle Antibodies  >10 publications with FLT4 and Muscle
 Heart Antibodies  >9 publications with FLT4 and Heart
 Bone Antibodies  >6 publications with FLT4 and Bone
 Lymph Node Antibodies  >5 publications with FLT4 and Lymph Node
 Brain Antibodies  >5 publications with FLT4 and Brain
 Intestine Antibodies  >4 publications with FLT4 and Intestine
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