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TGFB1 elisa kit :: Pig transforming growth factor, beta 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS701137
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,615 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,940 +6 FREE 8GB USB
 
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 Product Name   

transforming growth factor, beta 1 (TGFB1), ELISA Kit

★Popular Item★
 Also Known As   

Pig transforming growth factor beta1, TGF-beta1 ELISA Kit

 Product Synonym Names    Pig transforming growth factor beta1 (TGF-beta1) ELISA Kit; CED; DPD1; LAP; TGFB; TGFbeta; TGF-beta 1 protein; latency-associated peptide; transforming growth factor; beta 1
 Product Gene Name   

TGFB1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS701137 Testing Data    Testing Data PDF
 3D Structure    ModBase 3D Structure for P07200
 Species Reactivity    Pig
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Pig TGFB1. No significant cross-reactivity or interference between Pig TGFB1 and analogues was observed.
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 Samples    Serum, plasma
 Detection Range    0.78 ng/ml-50 ng/ml
 Sensitivity    0.195ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TGFB1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TGFB1 purchase    MBS701137 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the transforming growth factor, beta 1 (TGFB1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.78 ng/ml-50 ng/ml in biological research samples containing TGFB1, with an estimated sensitivity of 0.195ng/ml. The ELISA analytical biochemical technique of the MBS701137 kit is based on TGFB1 antibody-TGFB1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TGFB1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TGFB1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for TGFB1 elisa kit

   Introduction: Transforming growth factor beta 1 or TGF-beta1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. TGF-beta1 was first identified in human platelets as a protein with a molecular mass of 25 kilodaltons with a potential role in wound healing. It was later characterized as a large protein precursor (containing 390 amino acids) that was proteolytically processed to produce a mature peptide of 112 amino acids. TGF-beta1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-beta1. Some T cells (e.g. regulatory T cells) release TGF-beta1 to inhibit the actions of other T cells. Interleukin 1- and interleukin 2-dependent proliferation of activated T cells, and the activation of quiescent helper T cells and cytotoxic T cells is prevented by the activity of TGF-beta1. Similarly, TGF-beta1 can inhibit the secretion and activity of many other cytokines including interferon-gamma, tumor necrosis factor-alpha (TNF-alpha) and various interleukins. It can also decrease the expression levels of cytokine receptors, such as the IL-2 receptor to down-regulate the activity of immune cells. However, TGF-beta1 can also increase the expression of certain cytokines in T cells and promote their proliferation, particularly if the cells are immature. TGF-beta1 has similar effects on B cells that also vary according to the differentiation state of the cell. It inhibits proliferation and apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. The effects of TGF-beta1 on macrophages and monocytes are predominantly suppressive; this cytokine can inhibit the proliferation of these cells and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta1 can also have the opposite effect on cells of myeloid origin. For example, TGF-beta1 acts as a chemoattractant, directing an immune response to some pathogens; macrophages and monocytes respond to low levels of TGF-beta1 in a chemotactic manner. Furthermore, the expression of monocytic cytokines and phagocytic killing by macrophages can be increased by the action of TGF-beta1.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with goat-anti-rabbit antibody. Standards or samples are added to the appropriate microtiter plate wells with an antibody specific for TGF-beta1 and Horseradish Peroxidase (HRP) conjugated TGF-beta1, and incubated. A competitive inhibition reaction is launched between TGF-beta1 (Standards or samples) and Horseradish Peroxidase (HRP) conjugated TGF-beta1 with the antibody specific for TGF-beta1. Then substrate solutions are added to each well. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of TGF-beta1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of TGFB1 elisa kit    TGFB1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS701137. Click to request current manual
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NCBI/Uniprot data below describe general gene information for TGFB1. It may not necessarily be applicable to this product.
 NCBI GI #    55741797
 NCBI GeneID    397078
 NCBI Accession #    NP_999180.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_214015.1 [Other Products]
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 UniProt Primary Accession #    P07200 [Other Products]
 UniProt Secondary Accession #    P08832 [Other Products]
 UniProt Related Accession #    P07200 [Other Products]
 Molecular Weight    44,294 Da
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 NCBI Official Full Name    transforming growth factor beta-1
 NCBI Official Symbol    TGFB1 [Similar Products]
 NCBI Official Synonym Symbols   
TGF-BETA-1
[Similar Products]
 NCBI Protein Information    transforming growth factor beta-1; transforming growth factor-beta-1; transforming growth factor, beta 1 (Camurati-Engelmann disease)
 UniProt Protein Name    Transforming growth factor beta-1
 Protein Family    Transforming growth factor
 UniProt Gene Name    TGFB1 [Similar Products]
 UniProt Synonym Gene Names    TGF-beta-1; LAP [Similar Products]
 UniProt Entry Name    TGFB1_PIG
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 UniProt Comments for TGFB1    Function: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts
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 Research Articles on TGFB1    1. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10, and IL-6 in ovarian follicles are reported.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TGFB1 elisa kitPathways associated with TGFB1 elisa kit
 Reference Product  PubMed Publications
 TGFB2 elisa kit  >931 publications with TGFB1 and TGFB2
 CTGF elisa kit  >489 publications with TGFB1 and CTGF
 BMP2 elisa kit  >190 publications with TGFB1 and BMP2
 THBS1 elisa kit  >134 publications with TGFB1 and THBS1
 ENG elisa kit  >113 publications with TGFB1 and ENG
 TGFBR3 elisa kit  >81 publications with TGFB1 and TGFBR3
 DCN elisa kit  >80 publications with TGFB1 and DCN
 MMP2 elisa kit  >79 publications with TGFB1 and MMP2
 SPARC elisa kit  >57 publications with TGFB1 and SPARC
 TGFBR2 elisa kit  >45 publications with TGFB1 and TGFBR2
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
Diseases associated with TGFB1 elisa kitOrgans/Tissues associated with TGFB1 elisa kit
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >4845 publications with TGFB1 and Fibrosis
 Lung Diseases Antibodies  >1519 publications with TGFB1 and Lung Diseases
 Liver Cirrhosis Antibodies  >834 publications with TGFB1 and Liver Cirrhosis
 Pulmonary Fibrosis Antibodies  >754 publications with TGFB1 and Pulmonary Fibrosis
 Hypertension Antibodies  >713 publications with TGFB1 and Hypertension
 Proteinuria Antibodies  >494 publications with TGFB1 and Proteinuria
 Diabetic Nephropathies Antibodies  >462 publications with TGFB1 and Diabetic Nephropathies
 Hypersensitivity Antibodies  >443 publications with TGFB1 and Hypersensitivity
 Asthma Antibodies  >411 publications with TGFB1 and Asthma
 Diabetes Mellitus, Experimental Antibodies  >376 publications with TGFB1 and Diabetes Mellitus, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4332 publications with TGFB1 and Blood
 Muscle Antibodies  >2505 publications with TGFB1 and Muscle
 Kidney Antibodies  >2213 publications with TGFB1 and Kidney
 Bone Antibodies  >1917 publications with TGFB1 and Bone
 Liver Antibodies  >1531 publications with TGFB1 and Liver
 Lung Antibodies  >1518 publications with TGFB1 and Lung
 Connective Tissue Antibodies  >1392 publications with TGFB1 and Connective Tissue
 Skin Antibodies  >984 publications with TGFB1 and Skin
 Heart Antibodies  >912 publications with TGFB1 and Heart
 Bone Marrow Antibodies  >643 publications with TGFB1 and Bone Marrow
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