AAB84013.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,085 Da
NCBI Official Full Name
8-oxoguanine DNA glycosylase
NCBI Official Synonym Full Names
8-oxoguanine DNA glycosylase
NCBI Protein Information
N-glycosylase/DNA lyase
UniProt Protein Name
N-glycosylase/DNA lyase
UniProt Synonym Gene Names
NCBI Summary for OGG
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
UniProt Comments for OGG
OGG1: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Belongs to the type-1 OGG1 family. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: mitochondrion; nuclear matrix; nuclear speck; nucleoplasm; nucleus; protein complex
Molecular Function: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; damaged DNA binding; DNA N-glycosylase activity; endonuclease activity; microtubule binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; protein binding
Biological Process: acute inflammatory response; aging; base-excision repair; cellular response to DNA damage stimulus; depurination; depyrimidination; negative regulation of apoptosis; nucleotide-excision repair, DNA incision; regulation of protein import into nucleus, translocation; regulation of transcription, DNA-templated; response to drug; response to estradiol; response to ethanol; response to folic acid; response to light stimulus; response to oxidative stress; response to radiation
Disease: Renal Cell Carcinoma, Nonpapillary
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Products associated with OGG elisa kit
Pathways associated with OGG elisa kit
Diseases associated with OGG elisa kit
Organs/Tissues associated with OGG elisa kit
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