NP_000674.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,522 Da
NCBI Official Full Name
alpha-2C adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2C
NCBI Official Synonym Symbols
ADRA2L2; ADRARL2; ADRA2RL2; ALPHA2CAR [Similar Products]
NCBI Protein Information
alpha-2C adrenergic receptor; alpha-2CAR; alpha2-AR-C4; alpha-2C adrenoceptor; alpha-2C adrenoreceptor; alpha-2C-adrenergic receptor; adrenergic, alpha-2C-, receptor; alpha-2 adrenergic receptor subtype C4
UniProt Protein Name
Alpha-2C adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C4; Alpha-2C adrenoreceptor
UniProt Synonym Gene Names
UniProt Entry Name
ADA2C_HUMAN
NCBI Summary for ADRalpha2C
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
UniProt Comments for ADRalpha2C
ADRA2C: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 4p16
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; nerve terminal; endosome
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; alpha2-adrenergic receptor activity; epinephrine binding; alpha-2A adrenergic receptor binding
Biological Process: platelet activation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; activation of protein kinase B; positive regulation of vasoconstriction; negative regulation of epinephrine secretion; energy reserve metabolic process; regulation of sensory perception of pain; female pregnancy; blood coagulation; positive regulation of neuron differentiation; regulation of insulin secretion
Research Articles on ADRalpha2C
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Products associated with ADRalpha2C elisa kit
Pathways associated with ADRalpha2C elisa kit
Diseases associated with ADRalpha2C elisa kit
Organs/Tissues associated with ADRalpha2C elisa kit
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