NP_072092.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,627 Da
NCBI Official Full Name
C-type lectin domain family 7 member A isoform b
NCBI Official Synonym Full Names
C-type lectin domain family 7, member A
NCBI Protein Information
C-type lectin domain family 7 member A; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
UniProt Protein Name
C-type lectin domain family 7 member A
UniProt Synonym Protein Names
Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1
UniProt Synonym Gene Names
BGR; CLECSF12; DECTIN1; DC-associated C-type lectin 1; Dectin-1 [Similar Products]
UniProt Entry Name
CLC7A_HUMAN
NCBI Summary for CLEC3B
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
UniProt Comments for CLEC3B
dectin-1: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: cytoplasm; integral to membrane; plasma membrane
Molecular Function: metal ion binding; MHC protein binding; carbohydrate binding; pattern recognition receptor activity
Biological Process: T cell activation; innate immune response; phagocytosis, recognition; cell recognition; carbohydrate mediated signaling; pattern recognition receptor signaling pathway; defense response to protozoan; inflammatory response
Disease: Candidiasis, Familial, 4; Aspergillosis, Susceptibility To
Research Articles on CLEC3B
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Pathways associated with CLEC3B elisa kit
Diseases associated with CLEC3B elisa kit
Organs/Tissues associated with CLEC3B elisa kit
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