NP_001933.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
113,748 Da
NCBI Official Full Name
desmoglein-1 preproprotein
NCBI Official Synonym Full Names
desmoglein 1
NCBI Protein Information
desmoglein-1; DGI; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen
UniProt Protein Name
Desmoglein-1
UniProt Synonym Protein Names
Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
UniProt Synonym Gene Names
UniProt Entry Name
DSG1_HUMAN
NCBI Summary for DSG1
Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. [provided by RefSeq, Jul 2008]
UniProt Comments for DSG1
DSG1: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1); also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component: desmosome; internal side of plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; intercellular junction; cytosol; lateral plasma membrane
Molecular Function: toxin binding; gamma-catenin binding; calcium ion binding
Biological Process: intercellular junction assembly; cell-cell adhesion; maternal process involved in pregnancy; protein stabilization; apoptosis; calcium-dependent cell-cell adhesion; homophilic cell adhesion; response to progesterone stimulus; cell structure disassembly during apoptosis
Disease: Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse; Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-ige
Research Articles on DSG1
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Products associated with DSG1 elisa kit
Pathways associated with DSG1 elisa kit
Diseases associated with DSG1 elisa kit
Organs/Tissues associated with DSG1 elisa kit
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