NP_002194.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,295 Da
NCBI Official Full Name
integrin alpha-2
NCBI Official Synonym Full Names
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
NCBI Official Synonym Symbols
BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2 [Similar Products]
NCBI Protein Information
integrin alpha-2; collagen receptor; platelet antigen Br; platelet glycoprotein GPIa; VLA2 receptor, alpha-2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; human platelet alloantigen system 5; very late activation protein 2 receptor, alpha-2 subunit
UniProt Protein Name
Integrin alpha-2
UniProt Synonym Protein Names
CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha
UniProt Synonym Gene Names
UniProt Entry Name
ITA2_HUMAN
NCBI Summary for IG-alpha2beta1
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Comments for IG-alpha2beta1
ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.; Cell adhesion
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: focal adhesion; cell surface; perinuclear region of cytoplasm; plasma membrane; nerve terminal; nucleus; integrin complex; external side of plasma membrane
Molecular Function: integrin binding; viral receptor activity; collagen binding; protein binding; protein heterodimerization activity; metal ion binding; laminin binding
Biological Process: axon guidance; entry of virus into host cell; extracellular matrix organization and biogenesis; response to muscle activity; positive regulation of cell adhesion; positive regulation of positive chemotaxis; positive regulation of translation; cell-matrix adhesion; positive regulation of smooth muscle cell proliferation; positive regulation of leukocyte migration; positive regulation of collagen biosynthetic process; positive regulation of collagen binding; positive regulation of cell projection organization and biogenesis; mesodermal cell differentiation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to organic cyclic substance; establishment of protein localization; mammary gland development; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; substrate-bound cell migration; integrin-mediated signaling pathway; response to drug; skin morphogenesis; hypotonic response; cell-substrate adhesion; cellular response to hormone stimulus; detection of mechanical stimulus involved in sensory perception of pain; cell proliferation; organ morphogenesis; response to hypoxia; cell adhesion mediated by integrin; blood coagulation; positive regulation of phagocytosis, engulfment; positive regulation of inflammatory response; positive regulation of transmission of nerve impulse; response to amine stimulus
Disease: Bleeding Disorder, Platelet-type, 9
Research Articles on IG-alpha2beta1
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Products associated with IG-alpha2beta1 elisa kit
Pathways associated with IG-alpha2beta1 elisa kit
Diseases associated with IG-alpha2beta1 elisa kit
Organs/Tissues associated with IG-alpha2beta1 elisa kit
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