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JK elisa kit :: Pigeon Janus Kinase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS062830 JK elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Janus Kinase (JK), ELISA Kit

 Also Known As   

Pigeon Janus Kinase ELISA Kit

 Product Gene Name   

JK elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 9; NC_000009.11 (4985245..5128183). Location: 9p24
 OMIM    147796
 3D Structure    ModBase 3D Structure for O60674
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 Species Reactivity    Pigeon
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of JK elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for JK purchase    MBS062830 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Janus Kinase (JK) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing JK. The ELISA analytical biochemical technique of the MBS062830 kit is based on JK antibody-JK antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect JK antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, JK. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for JK. It may not necessarily be applicable to this product.
 NCBI GI #    62836431
 NCBI GeneID    3717
 NCBI Accession #    AAY16348.1 [Other Products]
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 UniProt Primary Accession #    O60674 [Other Products]
 UniProt Secondary Accession #    O14636; O75297 [Other Products]
 UniProt Related Accession #    O60674 [Other Products]
 Molecular Weight    130,674 Da
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 NCBI Official Full Name    Janus kinase
 NCBI Official Synonym Full Names    Janus kinase 2
 NCBI Official Symbol    JAK2 [Similar Products]
 NCBI Official Synonym Symbols   
JTK10; THCYT3
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase JAK2; JAK-2; Janus kinase 2 (a protein tyrosine kinase)
 UniProt Protein Name    Tyrosine-protein kinase JAK2
 UniProt Synonym Protein Names   
Janus kinase 2
 Protein Family    Janus kinase and microtubule-interacting protein
 UniProt Gene Name    JAK2 [Similar Products]
 UniProt Synonym Gene Names    JAK-2 [Similar Products]
 UniProt Entry Name    JAK2_HUMAN
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 NCBI Summary for JK    This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JK    JAK2: a non-receptor tyrosine-kinase involved in a specific subset of cytokine receptor signaling pathways, including IL-3, -5 and GM-CSF. Interacts with IL23R, SKB1 and STAM2. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. Fusion of Jak2 to TEL1 (ETV6) by t(9;12)(p24;p13) causes myeloproliferative disease in humans and mouse models. The Jak inhibitor AG490 inhibits constitutive Jak2 phosphorylation and causes apoptosis in cells from breast cancer and relapsing acute lymphoblastic leukemia. A single activating mutation is associated with several hematological malignancies. Inhibitor: AG490.

Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Oncoprotein; Protein kinase, TK; TK group; JakA family

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: nucleoplasm; extrinsic to internal side of plasma membrane; nuclear matrix; cytoskeleton; cytoplasm; caveola; nucleus; cytosol; lipid raft

Molecular Function: protein C-terminus binding; histone binding; acetylcholine receptor binding; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; interleukin-12 receptor binding; protein kinase activity; protein binding; growth hormone receptor binding; peptide hormone receptor binding; insulin receptor substrate binding; protein-tyrosine kinase activity; heme binding; phosphoinositide 3-kinase binding; SH2 domain binding; type 1 angiotensin receptor binding; ATP binding; receptor binding

Biological Process: establishment and/or maintenance of chromatin architecture; positive regulation of nitric oxide biosynthetic process; activation of MAPKK activity; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; tyrosine phosphorylation of JAK2 protein; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; response to antibiotic; regulation of apoptosis; elevation of cytosolic calcium ion concentration; tumor necrosis factor-mediated signaling pathway; erythrocyte differentiation; mesoderm development; negative regulation of neuron apoptosis; positive regulation of DNA binding; positive regulation of cell activation; positive regulation of protein import into nucleus, translocation; axon regeneration; positive regulation of insulin secretion; JAK-STAT cascade; positive regulation of tumor necrosis factor production; tyrosine phosphorylation of Stat5 protein; positive regulation of phosphoinositide 3-kinase cascade; tyrosine phosphorylation of STAT protein; positive regulation of peptidyl-tyrosine phosphorylation; mineralocorticoid receptor signaling pathway; response to hydroperoxide; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of cell differentiation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; hormone-mediated signaling; negative regulation of heart contraction; apoptosis; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; signal transduction; host programmed cell death induced by symbiont; negative regulation of cell proliferation; actin filament polymerization; positive regulation of cell proliferation; cell differentiation; STAT protein nuclear translocation; caspase activation; cell migration; cytokine and chemokine mediated signaling pathway; negative regulation of DNA binding; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of interleukin-1 beta production; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of inflammatory response; innate immune response; negative regulation of cell-cell adhesion; cell motility; blood coagulation; induction of apoptosis by oxidative stress; positive regulation of cell migration; positive regulation of inflammatory response

Disease: Polycythemia Vera; Myelofibrosis; Erythrocytosis, Familial, 1; Budd-chiari Syndrome; Thrombocythemia 3
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 Research Articles on JK    1. Patients positive for the JAK2V617F mutation had markedly higher activation of caspase-3
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with JK elisa kitPathways associated with JK elisa kit
 Reference Product  PubMed Publications
 STAT3 elisa kit  >1216 publications with JK and STAT3
 STAT1 elisa kit  >586 publications with JK and STAT1
 EPOR elisa kit  >176 publications with JK and EPOR
 GHR elisa kit  >160 publications with JK and GHR
 SOCS3 elisa kit  >159 publications with JK and SOCS3
 SOCS1 elisa kit  >150 publications with JK and SOCS1
 PTPN11 elisa kit  >93 publications with JK and PTPN11
 PRLR elisa kit  >71 publications with JK and PRLR
 CSF2RB elisa kit  >24 publications with JK and CSF2RB
 SH2B1 elisa kit  >18 publications with JK and SH2B1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
Diseases associated with JK elisa kitOrgans/Tissues associated with JK elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1615 publications with JK and Neoplasms
 Leukemia Antibodies  >1108 publications with JK and Leukemia
 Polycythemia Antibodies  >890 publications with JK and Polycythemia
 Polycythemia Vera Antibodies  >855 publications with JK and Polycythemia Vera
 Thrombocythemia, Essential Antibodies  >649 publications with JK and Thrombocythemia, Essential
 Primary Myelofibrosis Antibodies  >522 publications with JK and Primary Myelofibrosis
 Thrombocytosis Antibodies  >510 publications with JK and Thrombocytosis
 Cardiovascular Diseases Antibodies  >434 publications with JK and Cardiovascular Diseases
 Leukemia, Myeloid, Acute Antibodies  >297 publications with JK and Leukemia, Myeloid, Acute
 Inflammation Antibodies  >234 publications with JK and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >628 publications with JK and Bone
 Bone Marrow Antibodies  >580 publications with JK and Bone Marrow
 Vascular Antibodies  >374 publications with JK and Vascular
 Liver Antibodies  >312 publications with JK and Liver
 Muscle Antibodies  >273 publications with JK and Muscle
 Brain Antibodies  >213 publications with JK and Brain
 Kidney Antibodies  >158 publications with JK and Kidney
 Spleen Antibodies  >142 publications with JK and Spleen
 Lung Antibodies  >119 publications with JK and Lung
 Mammary Gland Antibodies  >75 publications with JK and Mammary Gland
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