BAB40977.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,439 Da
NCBI Official Full Name
SMAD4
NCBI Official Synonym Full Names
SMAD family member 4
NCBI Protein Information
mothers against decapentaplegic homolog 4; MAD homolog 4; SMAD, mothers against DPP homolog 4; deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; mothers against decapentaplegic, Drosophila, homolog of, 4
UniProt Protein Name
Mothers against decapentaplegic homolog 4
UniProt Synonym Protein Names
Deletion target in pancreatic carcinoma 4; SMAD family member 4
UniProt Synonym Gene Names
DPC4; MADH4; MAD homolog 4; Mothers against DPP homolog 4; SMAD 4; Smad4; hSMAD4 [Similar Products]
UniProt Entry Name
SMAD4_HUMAN
NCBI Summary for SMAD4
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
UniProt Comments for SMAD4
SMAD4: transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; DNA-binding
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: nucleoplasm; centrosome; transcription factor complex; nuclear chromatin; cytoplasm; nucleus; cytosol
Molecular Function: collagen binding; identical protein binding; protein binding; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity; protein homodimerization activity; DNA binding; sequence-specific DNA binding; metal ion binding; chromatin binding; transcription factor activity
Biological Process: axon guidance; developmental growth; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; sebaceous gland development; palate development; negative regulation of transcription from RNA polymerase II promoter; BMP signaling pathway; negative regulation of cell proliferation; regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; mesoderm development; neural crest cell differentiation; positive regulation of BMP signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of transforming growth factor-beta2 production; regulation of binding; transcription, DNA-dependent; in utero embryonic development; neuron fate commitment; positive regulation of transforming growth factor beta receptor signaling pathway; gastrulation with mouth forming second; somite rostral/caudal axis specification; SMAD protein complex assembly; formation of anatomical boundary; endothelial cell activation; cell proliferation; ureteric bud branching; response to hypoxia; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of hair follicle development; negative regulation of cell growth; negative regulation of protein catabolic process; negative regulation of transcription, DNA-dependent; endoderm development
Disease: Pancreatic Cancer; Juvenile Polyposis Syndrome; Myhre Syndrome; Juvenile Polyposis/hereditary Hemorrhagic Telangiectasia Syndrome
Research Articles on SMAD4
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Pathways associated with SMAD4 elisa kit
Diseases associated with SMAD4 elisa kit
Organs/Tissues associated with SMAD4 elisa kit
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