NP_207041.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,933 Da
NCBI Official Full Name
neutrophil activating protein NapA
NCBI Protein Information
neutrophil activating protein NapA
UniProt Protein Name
DNA protection during starvation protein
UniProt Synonym Protein Names
Bacterioferritin; HP-NAP; Neutrophil-activating protein A
UniProt Synonym Gene Names
UniProt Entry Name
DPS_HELPY
UniProt Comments for NAP3
Function: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction
By similarity. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulation of neutrophils and monocytes at the site of infection. Induces superoxide anion generation, adhesion and chemotaxis of neutrophils, through a pertussis toxin-sensitive pathway involving MAP kinases. Ref.2 Ref.11 Ref.14 Ref.15 Ref.16 Ref.17
Catalytic activity: 2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O.
Subunit structure: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe3+ can be deposited. Ref.13 Ref.18
Subcellular location: Cytoplasm.
Domain: 12 di-nuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes
By similarity.
Miscellaneous: According to Ref.16, colocalizes with DNA but according to Ref.12 it does not interact with DNA.
Sequence similarities: Belongs to the Dps family.
Research Articles on NAP3
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