CAA62219.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,187 Da
NCBI Official Full Name
11beta-hydroxysteroid dehydrogenase 2, partial
NCBI Official Synonym Full Names
hydroxysteroid 11-beta dehydrogenase 2
NCBI Official Synonym Symbols
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 2
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 2
UniProt Synonym Protein Names
11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; 11-beta-HSD2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase
UniProt Synonym Gene Names
UniProt Entry Name
DHI2_MOUSE
UniProt Comments for 11B-HSD2
HSD11B2: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). An autosomal recessive form of low-renin hypertension. It is usually diagnosed within the first years of life and is characterized by polyuria and polydipsia, failure to thrive, hypernatremia, severe hypertension with low renin and aldosterone levels, profound hypokalemia with metabolic alkalosis, and most often nephrocalcinosis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; EC 1.1.1.-; Oxidoreductase
Cellular Component: cytoplasm; intracellular membrane-bound organelle
Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity; NAD binding; steroid binding
Biological Process: aldosterone mediated regulation of blood volume; female pregnancy; glucocorticoid metabolic process
Research Articles on 11B-HSD2
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Pathways associated with 11B-HSD2 elisa kit
Diseases associated with 11B-HSD2 elisa kit
Organs/Tissues associated with 11B-HSD2 elisa kit
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