AAL90442.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,589 Da
NCBI Official Full Name
APRIL
NCBI Official Synonym Full Names
tumor necrosis factor superfamily member 13
NCBI Official Synonym Symbols
APRIL; CD256; TALL2; ZTNF2; TALL-2; TNLG7B; TRDL-1; UNQ383/PRO715 [Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 13
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 13
UniProt Synonym Protein Names
A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD_antigen: CD256
UniProt Synonym Gene Names
UniProt Entry Name
TNF13_HUMAN
NCBI Summary for APRIL
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
UniProt Comments for APRIL
TNFSF13: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Belongs to the tumor necrosis factor family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm; cytosol; extracellular region; nucleoplasm
Molecular Function: receptor binding
Biological Process: positive regulation of cell proliferation; positive regulation of isotype switching to IgA isotypes; regulation of mRNA stability; signal transduction; tumor necrosis factor-mediated signaling pathway
Research Articles on APRIL
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Products associated with APRIL elisa kit
Pathways associated with APRIL elisa kit
Diseases associated with APRIL elisa kit
Organs/Tissues associated with APRIL elisa kit
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